The development of pharmacogenomic models to predict drug response

Current Opinion in Drug Discovery and Development

Volumn 4, Issue 3, 2001, Pages 296-300

  Adam, G I R ^a  

^a Gemini Genomics AB   (Sweden)

Author keywords

ADME Tox; Medicine response profile; Principle component analysis; Single nucleotide polymorphism

Indexed keywords

BIOSTATISTICS; COHORT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DRUG DESIGN; DRUG RESPONSE; GENE MAPPING; HEALTH CARE; MARKER GENE; PHARMACOGENOMICS; PREDICTION; PUBLICATION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT PLANNING;

DRUG INDUSTRY; GENOMICS; GENOTYPE; MODELS, MOLECULAR; PHARMACOLOGY;

EID: 0034981437     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. The Genome International Sequencing Consortium: The human genome
2. The sequence of the human genome
3. A 4-Mb high-density single nucleotide polymorphism-based map around human APOE
4. A cSNP map and database for human chromosome 21
5. Drug firms to create public database of genetic mutations
6. Pharmacogenomics: Translating functional genomics into therapeutics
7. Curagen lays down markers, 120,000 of them
8. Genset-Abbott deal heralds pharmacogenomics era
9. Pharmacogenetics
10. Advances in pharmacogenetics and pharmacogenomics
11. Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
12. Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
13. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment
14. Kr potassium-channels with HERG and is associated with cardiac arrhytmia
15. Influence of the angiotensin II type I receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals
16. Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition
17. Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure
18. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis
19. Pharmacogenomics: A new approach to individual therapy of hypertension
20. Disruption of p53 in human cancer cells alters the responses to therapeutic agents
21. The role of pharmacogenetics and pharmacogenomics in chemotherapy with 5-fluorouracil
22. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease
23. Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease
24. Pharmacogenomics of psychiatric disorders
25. Ethical considerations in clinical pharmacogenomics research
26. Discovery, scoring and utilization of human single nucleotide polymorphisms: A multidisciplinary problem
27. Genotools SNP manager: A new software for automated high-throughput MALDI-TOF mass spectrometry SNP genotyping
28. A novel procedure for efficient genotyping of single nucleofide polymorphisms
29. Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity
30. Genomic profiling of drug sensitivities via induced haploinsufficiency
31. Research suggests importance of haplotypes over SNPs
32. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
33. Prospective CYP2D6 genotyping as an exclusion criteria for enrollment of a phase III clinical trial
34. Putting the code to work: The promise of pharmacogenetics and pharmacogenomics
35. Pharmacogenomics: Teaching old drugs new tricks
36. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
37. CCK receptor polymorphisms: An illustration of emerging themes in pharmacogenomics
38. Pharmacogenetics and the practice of medicine