메뉴 건너뛰기




Volumn 4, Issue 3, 2001, Pages 314-318

Design strategies for building drug-like chemical libraries

Author keywords

ADME; Computational; Drug like; Metabolism; Solubility; Toxicity

Indexed keywords

NEW DRUG;

EID: 0034980970     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (43)
  • 4
    • 0002720633 scopus 로고    scopus 로고
    • How can we optimize selection of drug development candidates from many compounds at the discovery stage?
    • (1999) Modem Drug Discovery , vol.2 , Issue.1 , pp. 55-60
    • Lipper, R.A.1
  • 5
    • 0031472588 scopus 로고    scopus 로고
    • Role of pharmacokinetics and metabolism in drug discovery and development
    • (1997) Pharm Rev , vol.49 , Issue.4 , pp. 403-449
    • Lin, H.L.1    Lu, A.Y.2
  • 6
    • 0033965260 scopus 로고    scopus 로고
    • Cheminformatics - Predicting the physicochemical properties of 'drug-like' molecules
    • (2000) Curr Opin Biotechnol , vol.11 , Issue.1 , pp. 104-107
    • Blake, J.F.1
  • 11
    • 0033952168 scopus 로고    scopus 로고
    • Compound optimization in early- and late-phase drug discovery: Acceptable pharmacokinetic properties utilizing combined physicochemical, in vitro and in vivo screens
    • (2000) Curr Opin Drug Discovery Dev , vol.3 , Issue.1 , pp. 30-41
    • Caldwell, G.W.1
  • 13
    • 0032841864 scopus 로고    scopus 로고
    • The correlation and prediction of the solubility of compounds in water using an amended solvation energy relationship
    • (1999) J Pharm Sci , vol.88 , Issue.9 , pp. 868-880
    • Abraham, M.H.1    Le, J.2
  • 15
    • 0001645890 scopus 로고    scopus 로고
    • Estimation of aqueous solubility for a diverse set of organic compounds based on molecular topology
    • (2000) J Chem Inf Comput Sci , vol.40 , Issue.3 , pp. 773-777
    • Huuskonen, J.1
  • 19
    • 0033587166 scopus 로고    scopus 로고
    • Molecular hashkeys: A novel method for molecular characterization and its importance for predicting important pharmaceutical properties of molecules
    • (1999) J Med Chem , vol.42 , Issue.10 , pp. 1739-1748
    • Ghuloum, A.M.1    Sage, C.R.2    Jain, A.N.3
  • 22
    • 0033840471 scopus 로고    scopus 로고
    • Predicting human oral bioavailability of a compound: Development of a novel quantitative structure-bioavailability relationship
    • (2000) Pharm Res , vol.17 , Issue.6 , pp. 639-644
    • Andrews, C.W.1    Bennett, L.2    Xu, L.X.3
  • 26
    • 0034609833 scopus 로고    scopus 로고
    • Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties
    • (2000) J Med Chem , vol.43 , Issue.20 , pp. 3714-3717
    • Ertl, P.1    Rohde, B.2    Selzer, P.3
  • 34
    • 0004856784 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.