Asymmetric catalytic ene-cyclization approach to 2-fluoro- 19-nor-1,25-dihydroxyvitamin D3 A-ring analog with significant transactivation activity

Chirality

Volumn 13, Issue 7, 2001, Pages 366-371

  Mikami, Koichi ^a   Ohba, Shiho ^a   Ohmura, Hirofumi ^b   Kubodera, Noboru ^b   Nakagawa, Kimie ^c   Okano, Toshio ^c  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

2 fluorinated A ring analog of 19 nor 1 ,25(OH)2D3; Apoptosis; Asymmetric catalysis; Cancer cells; Carbonyl ene reaction; Monocytic differentiation; Transactivation

Indexed keywords

CALCITRIOL; VITAMIN D RECEPTOR;

APOPTOSIS; ARTICLE; CANCER THERAPY; CATALYSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFORMATION; CYCLIZATION; DRUG STRUCTURE; EPOXIDATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PSORIASIS; TRANSACTIVATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CALCITRIOL; HUMANS; MOLECULAR CONFORMATION; OSTEOSARCOMA; PROTEIN CONFORMATION; RATS; RECEPTORS, CALCITRIOL; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034977392     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.1046     Document Type: Article

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