Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes

Chemical Research in Toxicology

Volumn 14, Issue 6, 2001, Pages 694-701

  Lakehal, F ^a,b   Dansette, P M ^c   Becquemont, L ^d   Lasnier, E ^a,e   Delelo, R ^a,f   Balladur, P ^a,f   Poupon, R ^a,g   Beaune, P H ^a   Housset, C ^a,g  

^a INSERM   (France)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d Service de Pharmacologie   (France)

^e HÔpital Européen Georges Pompidou   (France)

^f Chirurgie Générale and Centre de Recherches Chirurgicales   (France)

^g HÔPITAL SAINT ANTOINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5' HYDROXYMETHYLFLUCLOXACILLIN; CYTOCHROME P450 3A4; DEXAMETHASONE; DRUG METABOLITE; FLUCLOXACILLIN; LACTATE DEHYDROGENASE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BILE DUCT DISEASE; CELL CULTURE; CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG INDUCED DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; GALLBLADDER EPITHELIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0034973781     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0002435     Document Type: Article

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