Structure-function analysis of Yersinia pestis YopM's interaction with α-thrombin to rule on its significance in systemic plague and to model YopM's mechanism of binding host proteins

Microbial Pathogenesis

Volumn 30, Issue 4, 2001, Pages 193-209

  Hines, Judith ^a   Skrzypek, Elzbieta ^a   Kajava, Andrey V ^b   Straley, Susan C ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

Anti coagulant; LRR; Modelling; Thrombin; Yersinia; YopM

Indexed keywords

HIRUGEN; PROTEIN YOPM; THROMBIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BACTERIAL VIRULENCE; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PLAGUE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; YERSINIA PESTIS; YERSINIOSIS;

YERSINIA; YERSINIA PESTIS;

EID: 0034971956     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.2000.0424     Document Type: Article

References (50)

1. The virulence plasmid of Yersinia, an antihost genome
2. The yopM gene of Yersinia pestis encodes a released protein having homology with the human platelet surface protein GP1bα
3. The leucine-rich repeat: A versatile binding motif
4. YopM inhibits platelet aggegation and is necessary for virulence of Yersinia pestis in mice
5. Yersinia pestis YopM: Thrombin binding and overexpression
6. Interaction between Yersinia pestis YopM protein and human α-thrombin
7. Common themes in microbial pathogenecity revisited
8. Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleus
9. Structural and functional diversity in the leucine-rich repeat family of proteins
10. Proteins with leucine-rich repeats
11. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
12. Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats
13. Crystal structure of the spliceosomal U2B″-U2A′ protein complex bound to a fragment of U2 small nuclear RNA
14. The novel flightless-I gene brings together two gene families, actin-binding proteins related to gelsolin and leucine-rich-repeat proteins involved in Ras signal transduction
15. The role of leucine-rich repeat proteins in plant defences
16. Structural diversity of leucine-rich repeat proteins
17. 2+-response plasmid pCD1 of Yersinia pestis KIM5
18. Effect of Yersinia pestis YopM on experimental plague
19. Refined structure of the hirudin-thrombin complex
20. Quantitative evaluation of Escherichia coli host strains for tolerance to cytosine methylation in plasmid and phage recombinants
21. Detection and characterization of Yersinia pestis plasmids determining pesticin I, fraction I antigen, and 'mouse' toxin synthesis
22. Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis
23. Complete DNA sequence and detailed analysis of the Yersinia pestis KIM5 plasmid encoding murine toxin and capsular antigen
24. Yersinia pestis pH 6 anigen: Genetic, biochemical, and virulence characterization of a protein involved in the pathogenesis of bubonic plague
25. The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG
26. Conditionally replicative and conjugative plasmids carrying lacZa for cloning, mutagenesis, and allele replacement in bacteria
27. Thrombin interactions with hirudin
28. Crystallographic structures of thrombin complexed with thrombin receptor peptides: Existence of expected and novel binding modes
29. Structure of the hirugen and hirulog complexes of α-thrombin
30. The clot thickens: Clues provided by thrombin structure
31. The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
32. Heterogeneity of the Yersinia YopM protein
33. New strain of Yersinia enterocolitica pathogenic for rodents
34. A surface protease and the invasive character of plague
35. 2+ in Yersinia pestis include structural genes for outer membrane proteins
36. Trans-complementation-dependent replication of a low molecular weight origin fragment from plasmid R6K
37. Plasminogen acttvator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins
38. A rapid alkaline extraction procedure for screening recombinant plasmid DNA
39. Identification and cloning of a hemin storage locus involved in the pigmentation phenotype of Yersinia pestis
40. A PCR-based strategy for the rapid construction of defined bacterial deletion mutants
41. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
42. Electrophoretic transler of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications
43. A simple method of estimating fifty per cent endpoints
44. CHARMM: A program for macromolecular energy minimization, and dynamics calculations
45. Crystallographic R factor refinement by molecular dynamics
46. PROCHECK: A program to check the stereochemical quality of protein structures
47. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures