In vitro exposure to hydroxyurea reduces sickle red blood cell deformability

American Journal of Hematology

Volumn 67, Issue 3, 2001, Pages 151-156

  Huang, Zhi ^a   Louderback, Joseph G ^a   Bruce King, S ^a   Ballas, Samir K ^b   Kim Shapiro, Daniel B ^a  

^a WAKE FOREST UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Deformability; Erythrocyte; Hemoglobin; Hydroxyurea; Sickle cell disease

Indexed keywords

HEMOGLOBIN; HEMOGLOBIN F; HYDROXYUREA; METHEMOGLOBIN; OXYHEMOGLOBIN;

ARTICLE; BLOOD RHEOLOGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE GHOST; ERYTHROCYTE MEMBRANE; HUMAN; HUMAN CELL; OXIDATION; PRIORITY JOURNAL; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; ERYTHROCYTES, ABNORMAL; FETAL HEMOGLOBIN; HEMOGLOBINS; HUMANS; HYDROXYUREA; METHEMOGLOBIN; OXIDATION-REDUCTION; OXYHEMOGLOBINS;

EID: 0034970281     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.1098     Document Type: Article

References (28)

1. A specific chemical difference between the globins of normal human and sickle cell anemia hemoglobin
2. Oxidation-induced changes in microrheologic properties of the red-blood-cell membrane
3. Augmentation of fetal hemoglobin production in anemic monkeys by hydroxyurea
4. Hydroxyurea enhances fetal hemoglobin production in sickle-cell-anemia
5. The biophysics of sickle-cell hydroxyurea therapy
6. A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy
7. Effect of hydroxyurea on the frequency of painful crises in sickle-cell-anemia
8. Hydroxyurea and sickle cell anemia - Clinical utility of a myelosuppressive "switching" agent
9. Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults
10. Time resolved absorption study of the reaction of hydroxyurea with sickle cell hemoglobin
11. Nitrosylation of sickle cell hemoglobin by hydroxyurea
12. The reaction of deoxy-sickle cell hemoglobin with hydroxyurea
13. Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo
14. Treatment of myeloproliferative disorders with hydroxyurea: Effects on red blood cell geometry and deformability
15. Diffractometric method for measurement of cellular deformability
16. Osmotic gradient ektacytometry - Comprehensive characterization of red-cell volume and surface maintenance
17. Hydroxylamine and phenol-induced formation of methemoglobin and free radical intermediates in erythrocytes
18. The effects of xenobiotics on erythrocytes
19. Preparation and properties of α-and β-chains from human hemoglobin
20. The mechanism of in vitro formation of irreversibly sickled cells and modes of action of its inhibitors
21. Erythrocyte membrane deformability and stability: Two distinct membrane properties that are independently regulated by skeletal protein associations
22. The kinetics of resealing of washed erythrocyte ghosts
23. The sickle erythrocyte in double jeopardy - Autoxidation and iron decompartmentalization
24. Catalysis of soluble hemoglobin oxidation by free iron on sickle red cell membranes
25. Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea
26. Hydroxyurea - Effects on hemoglobin F production in patients with sickle cell anemia
27. Hydroxyurea affects cell morphology, cation-transport and red-blood-cell adhesion in cultured vascular endothelial cells