The use of stress proteins as a biomarker of sub-lethal toxicity: Induction of heat shock protein 70 by 2-isobutyl piperidine and transition metals at sub-lethal concentrations

Biomarkers

Volumn 6, Issue 3, 2001, Pages 204-217

  Gibney, E ^a   Gault, J ^a   Williams, J ^a  

^a SLIGO UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Heat shock proteins; Sub lethal toxicity; Transition metals

Indexed keywords

2 ISOBUTYL PIPERIDINE; BIOCHEMICAL MARKER; CADMIUM; COPPER; HEAT SHOCK PROTEIN 70; MERCURY; NEUTRAL RED; PIPERIDINE DERIVATIVE; SILVER; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; BEETLE; CELL LINE; CHEMICAL STRUCTURE; COLORADO POTATO BEETLE; CONCENTRATION RESPONSE; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; LETHALITY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; STAINING; STIMULUS RESPONSE; STRESS; TAXONOMY; TOXICITY; WESTERN BLOTTING;

ANIMALIA; COLEOPTERA; LEPTINOTARSA DECEMLINEATA; SOLANUM TUBEROSUM;

EID: 0034970194     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/13547500010009573     Document Type: Article

References (43)

1. A two-dimensional electrophoretic analysis of the heat-shock-induced proteins of human cells
2. The induction of gene activity in Drosophila by heat shock
3. Fathead minnow FHM cells for use in vitro cytotoxicity assays of aquatic pollutants
4. The control of protein synthesis during heat shock in Drosophila cells involves altered polypeptide elongation rates
5. Development of cytotoxicity tests for assessment of the toxicity of water samples taken from the environment
6. In vitro cytotoxicity assays: Potential alternatives to the Draize ocular irritancy test
7. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90)
8. Toxicity determined in vitro by morphological alterations and neutral red absorption
9. In vitro cytotoxicity of 150 chemicals to 3T3-L1 cells, assessed by the FRAME kenacid blue method
10. The heat shock response
11. Drosophila and yeast multigene families related to the Drosophila heat-shock genes
12. The heat shock response is self-regulated at both the transcriptional and posttranslational levels
13. Induction of the human hormone gene placed under human hsp70 promoter control in mouse cells: A quantitative indicator of heavy metal toxicity
14. One and two dimensional electrophoresis performed horizontally in ultra thin SDS pore gradient gels
15. Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesis several polypeptides
16. Recent applications of fish cell culture to biomedical research
17. A comparison of in vitro cytotoxicity assays and their application to water samples
18. The heat shock phenomena in cultured cells of rainbow trout hsp70 mRNA synthesis and turnover
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T-4
20. Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eucaryotic cells
21. A cell culture assay for the detection of cardiotoxicity
22. Protein measurement with the Folin phenol reagent
23. Sodium dodecyl sulphate polyacrylamide gel electrophoresis of serum after protein denaturation in the presence or absence of 2-mercaptoethanol
24. Detection of protein in polyacrylamide gels using an improved silver stain
25. The effect of heat shock on gene expression in Drosophila melanogaster
26. An evaluation of three in vitro cytotoxicity assays
27. Evaluation of heavy-metal ion toxicity in fish cells using a combined stress protein and cytotoxicity assay
28. Stress proteins: Potential as multitiered biomarkers
29. Stress proteins L-aquatic organisms: An environmental perspective
30. Uridine uptake inhibition as a cytotoxicity test: Correlations with the Draize test
31. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications
32. The error of determination of toxicity
33. Determination of the maximum acceptable toxicant concentration (MATC) and the safe concentration for certain aquatic pollutants
34. The heat shock response in cultured cells exposed to ethanol and its metabolites
35. How cells respond to stress
36. Stress proteins hsp60 and hsp70 in three species of amphipod exposed to cadmium, diazonin, dieldrin, and fluoranthene
37. Two-dimensional electrophoretic mapping of hepatic and renal stress proteins
38. Stress response of tomato cell cultures to toxic metals and heat shock: Differences and similarities
39. Induction of heat shock proteins in short-term cultured hepatocytes derived from normal and chronically griseofulvin-treated mice