The molecular pathogenesis of prostate cancer: Implications for prostate cancer prevention

Urology

Volumn 57, Issue 4, 2001, Pages 39-45

  Nelson, William G ^a   De Marzo, Angelo M ^a   DeWeese, Theodore L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED CANCER; ANTIGEN DETECTION; AUTOPSY; CANCER PREVENTION; CONFERENCE PAPER; EPITHELIUM CELL; HISTOPATHOLOGY; HUMAN; MALIGNANT TRANSFORMATION; PATHOGENESIS; PRIORITY JOURNAL; PROSTATE CANCER; RISK BENEFIT ANALYSIS;

ATROPHY; CELL TRANSFORMATION, NEOPLASTIC; DIET; DNA DAMAGE; DNA METHYLATION; GENE SILENCING; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; MALE; MIDDLE AGED; PROSTATE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; RISK FACTORS; TIME FACTORS; UNITED STATES;

EID: 0034970071     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-4295(00)00939-0     Document Type: Article

References (60)

1. The prostate: An increasing medical problem
2. Clinical evidence for and implications of the multistep development of prostate cancer
3. Prostate cancer in the era of prostate-specific antigen
4. Cancer control and quality of life following anatomical radical retropubic prostatectomy: Results at 10 years
5. Patterns of care and RTOG studies in prostate cancer: Long-term survival, hazard rate observations, and possibilities of cure
6. The epidemiology of prostate cancer part II: The risk factors
7. The epidemiology of prostate cancer part I: Descriptive epidemiology
8. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States
9. Latent carcinoma of prostate at autopsy in seven areas
10. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: An autopsy study of 249 cases
11. Lower prostate cancer risk in men with elevated plasma lycopene levels: Results of a prospective analysis
12. Energy, nutrient intake and prostate cancer risk: A population-based case-control study in Sweden
13. A prospective study of dietary fat and risk of prostate cancer
14. Diet, nutrition, and prostate cancer
15. Diet and prostatic cancer: A case-control study in Hawaii
16. Case-control studies of prostate cancer in blacks and whites in southern California
17. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues
18. Evidence of independent origin of multiple tumors from patients with prostate cancer
19. Allelic loss detected on chromosomes 8, 10, and 17 by fluorescence in situ hybridization using single-copy P1 probes on isolated nuclei from paraffin-embedded prostate tumors
20. Allelic imbalance and microsatellite instability in prostatic adenocarcinoma
21. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization
22. Fluorescence in situ hybridization analysis of 8p allelic loss and chromosome 8 instability in human prostate cancer
23. Allelic loss in locally metastatic, multisampled prostate cancer
24. Genetic alterations in prostate cancer
25. Stem cell features of benign and malignant prostate epithelial cells
26. CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia
27. CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain reaction: A new prostate cancer biomarker
28. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
29. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
30. Association between diet and age-related DNA modifications (I-compounds) in rat liver and kidney
31. Modulation of DNA modification (I-compound) levels in rat liver and kidney by dietary carbohydrate, protein, fat, vitamin, and mineral content
32. Chemoprevention of cancer
33. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
34. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
35. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
36. Rapid detection of inducers of enzymes that protect against carcinogens
37. Oxidants, antioxidants, and the degenerative diseases of aging
38. The causes and prevention of cancer
39. Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome
40. Models of DNA structure achieve almost perfect discrimination between normal prostate, benign prostatic hyperplasia (BPH), and adenocarcinoma and have a high potential for predicting BPH and prostate cancer
41. Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells
42. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450
43. Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer
44. Adduction of the heterocyclic amine food mutagens IQ and PhIP to mitochondrial and nuclear DNA in the liver of Fischer-344 rats
45. Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): Detection in paraffin-embedded sections and tissue distribution
46. The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods
47. Alterations in DNA methylation: A fundamental aspect of neoplasia
48. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells
49. DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture
50. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
51. Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis
52. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
53. Cloning, expression and chromosome locations of the human DNMT3 gene family
54. A mammalian protein with specific demethylase activity for mCpG DNA
55. Proliferative inflammatory atrophy of the prostate: Implications for prostatic carcinogenesis
56. Atrophy and hyperplasia in the prostate proper
57. Normal histology of the prostate
58. Histology and cellular kinetics of prostatic atrophy
59. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas