Isoform-specific transcriptional regulation by thyroid hormone receptors: Hormone-independent activation operates through a steroid receptor mode of coactivator interaction

Molecular Endocrinology

Volumn 15, Issue 7, 2001, Pages 1170-1185

  Yang, Z ^a   Privalsky, M L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN P160; STEROID HORMONE; STEROID RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR BETA2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; GENE SEQUENCE; GENETIC TRANSCRIPTION; HOMEOSTASIS; HORMONAL REGULATION; HORMONE ACTIVATION; HORMONE SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; TRANSCRIPTION REGULATION;

EID: 0034969460     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.15.7.0656     Document Type: Article

References (50)

1. A decade of molecular biology of retinoic acid receptors
2. The nuclear receptor superfamily: The second decade
3. Regulation of gene expression by nuclear hormone receptors
4. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
5. Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors
6. Nuclear receptors: Coactivators, corepressors and chromatin remodeling in the control of transcription
7. Nuclear receptor coactivators and corepressors
8. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
9. Co-activators and co-repressors in the integration of transcriptional responses
10. Coactivator and corepressor complexes in nuclear receptor function
11. Functions of thyroid hormone receptors in mice
12. Multiple isoforms of thyroid hormone receptor: An analysis of their relative contribution in mediating thyroid hormone action
13. Thyroid hormone receptors: Multiple forms, multiple possibilities
14. The mechanism of action of thyroid hormones
15. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
16. Repression of transcription mediated at a thyroid hormone response element by the v-Erb-A oncogene product
17. Activation and repression by nuclear hormone receptors: Hormone modulates an equilibrium between active and repressive states
18. Ligand-dependent and -independent transactivation by thyroid hormone receptor β-2 is determined by the structure of the hormone response element
19. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
20. Mechanism of corepressor binding and release from nuclear hormone receptors
21. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
22. Structure and specificity of nuclear receptor-coactivator interactions
23. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
24. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
25. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
26. A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor
27. Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
28. Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini
29. Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain
30. A unique role of the β-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation
31. Transcriptional anti-repression. Thyroid hormone receptor β-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex
32. The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription
33. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1
34. Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain
35. An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors
36. Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins
37. Contrasting developmental and tissue-specific expression of α and β thyroid hormone receptor genes
38. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
39. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
40. Estrogen receptor activation function 1 works by binding p160 coactivator proteins
41. Molecular and structural biology of thyroid hormone receptors
42. The thyroid hormone receptor-beta gene mutation R383H is associated with isolated central resistance to thyroid hormone
43. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
44. Thyroid hormone-independent interaction between the thyroid hormone receptor β 2 amino terminus and coactivators
45. The c-erb-A protein is a high-affinity receptor for thyroid hormone
46. The c-erb-A gene encodes a thyroid hormone receptor
47. Eukaryotic proteins expressed in Escherichia coli - An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
48. Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor
49. Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors