Fibrinogen longmont: A heterozygous abnormal fibrinogen with Bβ Arg-166 to Cys substitution associated with defective fibrin polymerization

Annals of the New York Academy of Sciences

Volumn 936, Issue , 2001, Pages 129-132

  Lounes, Karim C ^a   Lefkowitz, Jerry B ^b   Coates, Andrew I ^c   Hantgan, Roy R ^d   Henschen Edman, Agnes ^e   Lord, Susan T ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c The University of North Carolina at Chapel Hill   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bleeding disorders; Fibrin polymerization; Human abnormal fibrinogen; Lateral aggregation

Indexed keywords

ARGININE; BATROXOBIN; CALCIUM; CYSTEINE; DIMER; FIBRIN; FIBRINOGEN LONGMONT; FIBRINOGEN VARIANT; FIBRINOPEPTIDE A; FIBRINOPEPTIDE B; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; BLEEDING; BLOOD CLOTTING; CASE REPORT; CONFERENCE PAPER; FEMALE; FIBRIN POLYMERIZATION; HETEROZYGOSITY; HUMAN; LIGHT SCATTERING; PROTEIN BINDING;

EID: 0034968657     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03501.x     Document Type: Conference Paper

References (5)

1. Fibrinogen Longmont: A dysfibrinogenemia that causes prolonged clot-based test results only when using an optical detection method
2. Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin
3. Fibrinogen Lima: A homozygous dysfibrinogen with an Aα-arginine-141 to serine substitution associated with extra N-glycosylation at Aα-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator
4. Fibrinogen Niigata with impaired fibrin assembly: An inherited dysfibrinogen with a Bβ Asn-160 to Ser substitution associated with extra glycosylation at Bβ Asn-158
5. Structure of the fibrin protofibril