Discovery of leukotrienes and development of antileukotriene agents

Annals of Allergy, Asthma and Immunology

Volumn 86, Issue SUPPL. 1, 2001, Pages 4-8

  Leff, A R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 METHOXY 4 [(PHENYLSULFONYLAMINO)CARBONYL]BENZYL] 1H INDAZOLE 6 CARBAMIC ACID CYCLOPENTYL ESTER; 2 [4 [2 (5 TETRAZOLYLMETHYL)BENZYLOXY]PHENOXYMETHYL]QUINOLINE; 3 [(2 CARBOXYETHYL)THIO] 3 [2 (8 PHENYLOCTYL)PHENYL]PROPIONIC ACID; 4 (4 CARBOXYPHENYLTHIO) 7 [4 (4 PHENOXYBUTOXY)PHENYL] 5 HEPTENOIC ACID; 6 (4 CARBOXYPHENYLTHIO) 5 HYDROXY 7,9,11,14 ICOSATETRAENOIC ACID; 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; CGP 45715; IRALUKAST; LEUKOTRIENE; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; POBILUKAST; PRANLUKAST; SLOW REACTING SUBSTANCE; TOMELUKAST; VERLUKAST; ZAFIRLUKAST; ZILEUTON;

ASTHMA; BRONCHUS MUSCLE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; MEDIATOR RELEASE; MUSCLE CONTRACTION; PATHOGENESIS; PRIORITY JOURNAL; SYMPTOMATOLOGY;

EID: 0034968081     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1081-1206(10)62305-8     Document Type: Conference Paper

References (39)

1. Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases
2. Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid
3. Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds
4. Leukotriene B. Total synthesis and assignment of stereochemistry
5. Arachidonic acid metabolism in polymorphonuclear leukocytes: Unstable intermediate in formation of dihydroxy acids
6. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
7. Slow reacting substance and related compounds
8. The liberation of a slow-reacting smooth muscle-stimulating substance in anaphylaxis
9. Slow-reacting substance of anaphylaxis: Purification and characterisation
10. Arachidonic acid metabolism in polymorphonuclear leukocytes: Effects of ionophore A23187
11. Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187
12. Structure of leukotriene C. Identification of the amino acid part
13. Stereochemistry of leukotriene C1
14. Total synthesis of 5,6-oxido-7,9-trans, 11,14-cis-eicosapentaenoic acid, a possible precursor of SRS-A
15. Leukotriene D: A slow reacting substance from rat basophilic leukemia cells
16. The inhibitory effects of BW 755C on arachidonic acid metabolism in human polymorphonuclear leukocytes
17. Nomenclature for leukotrienes
18. Metabolism of leukotriene D by porcine kidney
19. Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation
20. Involvement of calcium in the thimerosal-stimulated formation of leukotriene by fMLP in human polymorphonuclear leukocytes
21. Studies on the activation of human neutrophil 5-lipoxygenase induced by natural agonists and Ca2+ ionophore A23187
22. 5-Lipoxygenase
23. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor
24. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4
25. Molecular cloning and expression of human leukotriene-C4 synthase
26. Formation and actions of leukotrienes
27. Leukotrienes as therapeutic target in asthma
28. Leukotriene B4 in inflammation
29. Leukotriene B: A potential mediator of inflammation
30. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro
31. An examination of the influence of the epithelium on contractile responses to peptidoleukotrienes and blockade by ICI 204,219 in isolated guinea pig trachea and human intralobar airways
32. A novel leukotriene antagonist, ONO-1078, inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro
33. Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro
34. A second cysteinyl leukotriene receptor in human lung
35. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes
36. Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist
37. The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate-asthma
38. The challenge of drug discovery: Developing leukotriene antagonists
39. Leukotriene receptors and their antagonists