Limited proteolysis of a disulfide-linked apoA-I dimer in reconstituted HDL

Journal of Lipid Research

Volumn 42, Issue 6, 2001, Pages 935-942

  Calabresi, L ^a   Tedeschi, G ^a   Treu, C ^a   Ronchi, S ^a   Galbiati, D ^a   Airoldi, S ^a   Sirtori, C R ^a   Marcel, Y ^a   Franceschini, G ^a  

^a Center E Grossi Paoletti   (Italy)

Author keywords

Apolipoprotein A IMilano; Limited proteolysis; Protein conformation

Indexed keywords

APOLIPOPROTEIN A1; DIMER; HIGH DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE; PROTEIN HYDROLYSATE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; DISULFIDE BOND; IMMUNOBLOTTING; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTIBODIES, MONOCLONAL; APOLIPOPROTEIN A-I; BLOTTING, WESTERN; DIMERIZATION; DISULFIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPE MAPPING; EPITOPES; HUMANS; IMMUNOBLOTTING; LIPOPROTEINS, HDL; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 0034967325     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Recombinant apolipoproteins for the treatment of vascular diseases
2. Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits
3. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice
4. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI
5. Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice
6. Drug control of reverse cholesterol transport
7. Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I
8. Activation of fibrinolysis by apolipoproteins of high density lipoproteins in man
9. Inhibition of VCAM-1 expression in endothelial cells by reconstituted high density lipoproteins
10. The amino acid sequence of human apoA-I, an apolipoprotein isolated from high density lipoprotein
11. Molecular basis of exchangeable apolipoprotein function
12. Conformational analysis of apolipoprotein A-I and E-3 based on primary sequence and circular dichroism
13. The amphipathic helix in the exchangeable apolipoproteins: A review of secondary structure and function
14. Crystal Structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
15. Reconstitution of high-density lipoproteins
16. Activation of lecithin cholesterol acyltransferase by a disulfide-linked apolipoprotein A-I dimer
17. Milano dimer
18. Lecithin-cholesterol acyltransferase in the metabolism of high-density lipoproteins
19. Apolipoprotein A-I conformation in discoidal particles: Evidence for alternate structures
20. The structure of human lipoprotein A-I. Evidence for the "belt" model
21. A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein
22. Defined apolipoprotein A-1 conformations in reconstituted high density lipoprotein discs
23. Predicting the structure of apolipoprotein A-I in reconstituted high-density lipoprotein disks
24. Milano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family
25. Milano. Detection of normal AI in affected subjects and evidence for a cysteine for arginine substitution in the variant AI
26. Milano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant
27. Milano dimer. The introduction of an interchain disulfide bridge remarkably alters the physicochemical properties of apolipoprotein A-I
28. Reconstituted high-density lipoproteins with a disulfide-linked apolipoprotein A-I dimer: Evidence for restricted particle size heterogeneity
29. Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions
30. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100kDa
31. A new enzymatic method for determination of serum choline-containing phospholipids
32. Protein measurement with the Folin phenol reagent
33. Circular dichroic analysis of protein conformation: Inclusion of the β-turns
34. The epitopes of apolipoprotein A-I define distinct structural domains including a mobile middle region
35. Immunochemical characterization of six monoclonal antibodies to human apolipoprotein A-I: Epitope mapping and expression
36. Structural and functional domains of apolipoprotein A-I within high density lipoproteins
37. Properties of an N-terminal proteolytic fragment of apolipoprotein AI in solution and in reconstituted high density lipoproteins
38. Correlation between sites of limited proteolysis and segmental mobility in thermolysin
39. Apolipoprotein A-I structure and lipid properties in homogeneous, reconstituted spherical and discoidal high density lipoproteins
40. Pre-beta high density lipoportein. Unique disposition of apolipoprotein A-I increases suceptibility to proteolysis
41. Apolipoprotein A-I conformation in reconstituted discoidal lipoproteins varying in phospholipid and cholesterol content
42. Molecular belt models for the apolipoprotein A-I Paris and Milano mutations
43. Enzymatic hydrolysis of reconstituted dimyristoylphosphatidylcholine-apo A-I complexes
44. Structural analysis of apolipoprotein A-I: Limited proteolysis of methionine-reduced and -oxidized lipid-free and lipid-bound human apo A-I
45. Milano, associated with familial hypoalphalipoproteinemia
46. Milano. Disulfide-linked dimers increase high density lipoprotein stability, and hinder particle interconversion in carrier plasma