A rapid method to identify cytotoxic T-lymphocyte peptide epitopes from HLA-A2 (+) donors

Critical Reviews in Oncology/Hematology

Volumn 39, Issue 1-2, 2001, Pages 133-138

  Castellanos, Mario R ^a   Weinstein, Gila ^a   Hayes, Roberta L ^a  

^a STATEN ISLAND UNIVERSITY HOSPITAL   (United States)

Author keywords

Cancer vaccine; Cytotoxic; Human papillomavirus; MHC class I; Peptide binding; T lymphocyte

Indexed keywords

AMINO ACID; CANCER VACCINE; EPITOPE; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; ONCOPROTEIN; PEPTIDE;

ALGORITHM; CHROMIUM 51 RELEASE; COMPUTER; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DONOR; HUMAN; HUMAN CELL; IMMUNOGENICITY; PEPTIDE SYNTHESIS; PERIPHERAL LYMPHOCYTE; PROTEIN BINDING; TECHNIQUE; WART VIRUS;

ALGORITHMS; AMINO ACID SEQUENCE; BLOOD DONORS; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES; HLA-A2 ANTIGEN; HUMANS; MODELS, MOLECULAR; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PEPTIDES; PROTEIN BINDING; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0034966942     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1040-8428(01)00112-3     Document Type: Conference Paper

References (9)

1. Cancer therapy: new concepts on active immunization
2. Human tumor antigens for cancer vaccine development
3. Role of HLA-A motifs identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins
4. Prominent role of secondary anchor residues in peptide binding to HLA-A2.1
5. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes
6. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains
7. Generation of tumor-specific cytotoxic T lymphocytes from peripheral blood of cervical cancer patients by in vitro stimulation with a synthetic human papillomavirus type 16 E7 epitope
8. An improved method for the detection of peptide-induced upregulation of HLA-A2 molecules on TAP-deficient T2 cells