Interaction mechanism between indoxyl sulfate, a typical uremic toxin bound to site II, and ligands bound to site I of human serum albumin

Pharmaceutical Research

Volumn 18, Issue 4, 2001, Pages 520-524

  Sakai, T ^a   Yamasaki, K ^a   Sako, T ^a   Kragh Hansen, U ^a,b   Suenaga, A ^a   Otagiri, M ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Allosteric interaction; Dansyl L asparagine; High affinity binding site; Human serum albumin; Indoxyl sulfate; N to B transition

Indexed keywords

INDICAN; SERUM ALBUMIN; UNCLASSIFIED DRUG; UREMIC TOXIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHRONIC KIDNEY FAILURE; DRUG PROTEIN BINDING; LIGAND BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL;

ANTICOAGULANTS; ASPARAGINE; BINDING SITES; DANSYL COMPOUNDS; FLUORESCENT DYES; HUMANS; HYDROGEN-ION CONCENTRATION; INDICAN; LIGANDS; SERUM ALBUMIN; TOXINS, BIOLOGICAL; UREMIA; WARFARIN;

EID: 0034960027     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011014629551     Document Type: Article

References (19)

1. Drug binding in renal disease
2. Decreased drug binding in uremia: Effect of indoxyl sulfate and other endogenous substances on the binding of drugs to human albumin
3. Effect of uremic toxins and fatty acid on serum protein binding of furosemide: Possible mechanism of the binding effect in uremia
4. Characterization of binding site of uremic toxins on human serum albumin
5. Structure of serum albumin
6. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites
7. Interactive binding to the two principal ligand binding sites of human serum albumin: Effect of the neutral-to-base transition
8. Removal of fatty acids from serum albumin by charcoal treatment
9. A pharmacokinetic analysis program (MULTI) for microcomputer
10. Relations between high-affinity binding sites of markers for binding regions on albumin
11. Molecular aspects of ligand binding to serum albumin
12. Independent binding of ligands to human serum albumin
13. The location of drug binding sites in human serum albumin
14. Characterization of site I on human serum albumin: Concept about the structure of a drug binding site
15. The effect of albumin conformation on the binding of warfarin to human serum albumin. The dependence of the binding of warfarin to human serum albumin on the hydrogen, calcium and chloride ion concentrations as studied by circular dichroism, fluorescence, and equilibrium dialysis
16. The role of albumin conformation in the binding of diazepam to human serum albumin
17. The effects of N-B transition of human serum albumin on the specific drug-binding sites
18. The molecular mechanism of the neutral-to-base transition of human serum albumin. An acid/base titration and proton nuclear magnetic resonance studies on a large peptic and a large tryptic fragment of albumin