Dose-dependent nonlinear pharmacokinetics of ethylene glycol metabolites in pregnant (GD 10) and nonpregnant sprague-dawley rats following oral administration of ethylene glycol

Toxicological Sciences

Volumn 62, Issue 1, 2001, Pages 10-19

  Pottenger, L H ^a   Carney, E W ^b   Bartels, M J ^b  

^a DOW EUROPE GMBH   (Switzerland)

^b DOW CHEMICAL COMPANY   (United States)

Author keywords

Developmental toxicity mechanisms; Ethylene glycol; Glycolic acid; Metabolism; Nonlinear pharmacokinetics; Pregnant rats

Indexed keywords

CARBON 13; ETHYLENE GLYCOL; GLYCOLIC ACID; OXALIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CANNULATION; CONTROLLED STUDY; DEVELOPMENT; DOSE RESPONSE; DRUG ELIMINATION; DRUG METABOLISM; EMBRYO; FEMALE; FETUS; GAS CHROMATOGRAPHY; GESTATIONAL AGE; HALF LIFE TIME; JUGULAR VEIN; MASS SPECTROMETRY; MATERNAL BLOOD; METABOLITE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARAMETER; PHARMACOKINETICS; PREGNANCY; RAT; TOXICITY; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CARBON ISOTOPES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE GLYCOL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCOLATES; NONLINEAR DYNAMICS; OXALIC ACID; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0034958667     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/62.1.10     Document Type: Article

References (25)

1. An integrated perspective on the developmental toxicity of ethylene glycol
2. Ethylene glycol developmental toxicity: Unraveling the roles of glycolic acid and metabolic acidosis
3. Identification of proximate toxicant for ethylene glycol developmental toxicity using rat whole embryo culture
4. Comparative pharmacokinetics and metabolism of ethylene glycol in pregnant rats and rabbits
5. Pharmacokinetics of ethylene glycol. I. Plasma disposition after single intravenous, peroral, or percutaneous doses in female Sprague-Dawley rats and CD-1 mice
6. Pharmacokinetics of ethylene glycol. II. Tissue distribution, dose-dependent elimination, and identification of urinary metabolites following single intravenous, peroral or percutaneous doses in the female mouse
7. Pharmacokinetics of ethylene glycol. III. Plasma disposition and metabolic fate after single increasing intravenous peroral or percutaneous doses in male Sprague-Dawley rats
8. Quantitative analysis for organic acids in biological samples: Batch isolation followed by gas chromatographic-mass spectrometric analysis
9. Methanol and ethylene glycol poisonings: Mechanism of toxicity, clinical course, diagnosis and treatment
10. Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis
11. Determination of glycolic acid level in higher plants during photorespiration by stable isotope dilution mass spectrometry with double-labelling experiments
12. Chemically induced alterations in maternal homeostasis and histology of conceptus: Their etiologic significance in rat fetal anomalies
13. Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis
14. Dose-dependent disposition of ethylene glycol in the rat after intravenous administration
15. Perinatal toxicology: Its recognition and fundamentals
16. Developmental toxicity study of glycolic acid in rats
17. Determination of a no-observed-effect-level for developmental toxicity of ethylene glycol administered by gavage to CD rats and CD-1 mice
18. Pathways of hepatic oxalate synthesis and their regulation
19. The developmental toxicity of ethylene glycol in rats and mice
20. Effects of sugars and vitamin B-6 deficiency on oxalate synthesis in rats
21. Gas-chromatographic method of analysis for urinary organic acids. II. Description of the procedure, and its application to diagnosis of patients with organic acidurias
22. Developmental toxicity evaluation of ethylene glycol by gavage in New Zealand White rabbits