Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos

Developmental Dynamics

Volumn 221, Issue 3, 2001, Pages 342-349

  Lagutin, Oleg ^a   Zhu, Changqi C ^a   Furuta, Yasuhide ^b   Rowitch, David H ^c   McMahon, Andrew P ^d   Oliver, Guillermo ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

Homeobox; Mouse; Optic vesicles; Pax6; Six3; Transgenic

Indexed keywords

ANIMAL TISSUE; ARTICLE; ECTODERM; ECTOPIC TISSUE; EMBRYO; EYE; EYE DEVELOPMENT; GENE; GENE EXPRESSION; HOMEOBOX; MESENCEPHALON; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHOMBENCEPHALON; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; DNA-BINDING PROTEINS; ECTODERM; EMBRYONIC AND FETAL DEVELOPMENT; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAD; HOMEODOMAIN PROTEINS; LENS, CRYSTALLINE; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PAX2 TRANSCRIPTION FACTOR; REPRESSOR PROTEINS; TIME FACTORS; TRANSCRIPTION FACTORS;

LATIPES; MURINAE; ORYZIAS LATIPES;

EID: 0034956322     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.1148     Document Type: Article

References (19)

1. Expanded retina territory by midbrain transformation upon overexpression of Six6 (optix2) in Xenopus embryos
2. Pax6 induces ectopic eyes in a vertebrate
3. DNA-binding and transactivation properties of Pax6: Three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5)
4. BMP4 is essential for lens induction in the mouse embryo
5. Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice
6. Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk
7. Overexpression of the forebrain-specific homeobox gene Six3 induces rostral forebrain enlargement in zebrafish
8. Six3 overexpression initiates the formation of ectopic retina
9. Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila
10. Homeobox genes and connective tissue patterning
11. Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
12. Ectopic lens induction in fish in response to the murine homeobox gene Six3
13. The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development
14. Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum
15. The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism
16. Six class homeobox genes in Drosophila belong to three distinct families and are involved in head development
17. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
18. The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes
19. Giant eyes in Xenopus laevis by overexpression of Xoptx2