Safety and pharmacokinetics of multiple 750-milligram doses of intravenous levofloxacin in healthy volunteers

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 7, 2001, Pages 2122-2125

  Chow, A T ^a   Fowler, C ^a   Williams, R R ^a   Morgan, N ^a   Kaminski, S ^a   Natarajan, J ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOFLOXACIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTI-INFECTIVE AGENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; OFLOXACIN;

EID: 0034956120     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.7.2122-2125.2001     Document Type: Article

References (14)

1. An information criterion (AIC)
2. Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses
3. Double-blind evaluation of the safety and pharmacokinetics of multiple oral once-daily 750-milligram and 1-gram doses of levofloxacin in healthy volunteers
4. Prediction of creatinine clearance from serum creatinine
5. A modified form of Levenberg's correction
6. Safety and efficacy of oral levofloxacin versus cefuroxime axetil in acute bacterial exacerbation of bronchitis
7. A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia
8. The clinical pharmacokinetics of levofloxacin
9. Multicenter, randomized study comparing efficacy and safety of oral levofloxacin and cefaclor in treatment of acute bacterial exacerbations of chronic bronchitis
10. A controlled trial of levofloxacin and lomefloxacin in the treatment of complicated urinary tract infection
11. Multicenter, randomized study comparing levofloxacin and ciprofloxacin for uncomplicated skin and skin structure infections
12. Noncompartmental determination of the steady-state volume of distribution during multiple dosing
13. Rapid stereospecific high-performance liquid chromatographic determination of levofloxacin in human plasma and urine