CYP2C19 genotype related effect of omeprazole on intragastric pH and antimicrobial stability

Pharmaceutical Research

Volumn 18, Issue 5, 2001, Pages 615-621

  Kita, Tomoko ^a   Tanigawara, Yusuke ^a,b   Aoyama, Nobuo ^a   Hohda, Takashi ^a   Saijoh, Yoshie ^a   Komada, Fusao ^a,c   Sakaeda, Toshiyuki ^a   Okumura, Katsuhiko ^c   Sakai, Toshiyuki ^a   Kasuga, Masato ^a  

^a KOBE UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c JOSAI UNIVERSITY   (Japan)

Author keywords

CYP2C19; Genotype; Helicobacter pylori; Intragastric pH; Omeprazole; Stability of antimicrobials

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; CLARITHROMYCIN; CYTOCHROME P450 2C19; METRONIDAZOLE; OMEPRAZOLE;

ADULT; ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG STABILITY; GENETIC POLYMORPHISM; GENOTYPE; HELICOBACTER PYLORI; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH PH;

AMOXICILLIN; ANTI-ULCER AGENTS; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; CLARITHROMYCIN; CYTOCHROME P-450 ENZYME SYSTEM; DRUG COMBINATIONS; DRUG STABILITY; GASTRIC ACIDITY DETERMINATION; GENOTYPE; HELICOBACTER PYLORI; HYDROGEN-ION CONCENTRATION; METRONIDAZOLE; MIXED FUNCTION OXYGENASES; OMEPRAZOLE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0034955440     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011025125163     Document Type: Article

References (31)

1. Molecular mechanisms of genetic polymorphisms of drug metabolism
2. A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype
3. Geographical/Interracial differences in polymorphic drug oxidation: Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19
4. The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: A population study
5. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
6. Identification of a new genetic defect responsible for the polymorphism of S- mephenytoin metabolism in Japanese
7. m2 in exon 4, in Japanese subjects
8. Genotyping of S-mephenytoin 4'-hydroxylation in an extended Japanese population
9. A sensitive non-radioactive PCR-RFLP analysis for detecting point mutation at 12th codon of oncogene c-Ha-ras in DNAs of gastric cancer
10. Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism
11. Clinical pharmacology of omeprazole
12. Double-blind trial of omeprazole and amoxicillin to cure Helicobacter pylori Infection in patients with duodenal ulcer
13. The MACH2 study: Role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies
14. Amoxicillin plus omeprazole versus triple therapy for eradication of Helicobacter pylori in duodenal ulcer disease: A prospective, randomised and controlled study
15. Review article: Treatments that impact favourably upon the eradication of Helicobacter pylori and ulcer recurrence
16. Helicobacterpylori eradication: Unravelling the facts
17. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: The MACH 1 study
18. Additive effect of clarithromycin combined with 14-hydroxy clarithromycin, erythromicin, amoxicillin, metronidazole or omeprazole against Helicobacter pylori
19. Effect of an acidic environment on the susceptibility of Helicobacter pylori to trospectomycin and other antimicrobial agents
20. The life and death of Helicobacter pylori
21. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice
22. Effect of omeprazole on concentrations of clarithromycin in plasma and gastric tissue at steady state
23. The stability of amoxicillin, clarithromycin and metronidazole in gastric juice: Relevance to the treatment of Helicobacter pylori infection
24. Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population
25. CYP2C19 genotype-related efficacy of omeprazole for the treatment of infection caused by Helicobacter pylori
26. Suffucuent effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers
27. Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer
28. Simultaneous determination of omeprazole and its metabolites in plasma and urine by reversed-phase highperformance liquid chromatography with an alkaline-resistant polymer-coated C 18 column
29. Intragastric acidity as a predictor of the success of Helicobacter pylori eradication: A study in peptic ulcer patients with omeprazole and amoxicillin
30. Prolonged and profound acid inhibition is crucial in Helicobacter pylori treatment with a proton pump inhibitor combined with amoxicillin
31. Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori