Fast lipid disorientation at the onset of membrane fusion revealed by molecular dynamics simulations

Biophysical Journal

Volumn 81, Issue 1, 2001, Pages 217-224

  Ohta Lino, Satoko ^a   Pasenkiewicz Gierula, Marta ^b,c   Takaoka, Yuji ^c   Miyagawa, Hiroh ^c   Kitamura, Kunihiro ^c   Kusumi, Akihiro ^a,d  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c TAISHO PHARMACEUTICAL CO LTD   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; MEMBRANE LIPID; MEMBRANE PHOSPHOLIPID;

ARTICLE; COMPUTER SIMULATION; DEHYDRATION; HYDROGEN BOND; LIPID ANALYSIS; MEMBRANE FUSION; MOLECULAR DYNAMICS; ORIENTATION;

EID: 0034950491     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0006-3495(01)75693-7     Document Type: Article

References (37)

1. Neutron diffraction studies on phosphatidylcholine model membrane
2. Structure of influenza haemagglutinin at the pH of membrane fusion
3. An early stage of membrane fusion mediated by the low pH conformation of influenza hemagglutinin depends upon membrane lipids
4. Physical interactions that determine the properties of proteins
5. Die berechnung optischer und elektrostatische gitterpotentiale
6. 2D NMR studies of the phosphate-water interaction in dipalmitoylphosphatidylcholine-water system
7. Molecular mechanisms and forces involved in the adhesion and fusion of amphiphilic bilayers
8. Role of hydrophobic forces in bilayer adhesion and fusion
9. Molecular motion in spinlabeled phospholipids and membranes
10. Membrane fusion of influenza virus with phosphatidylcholine liposomes containing viral receptors
11. Spin-label studies on phosphatidylcholine-cholesterol membranes: Effects of alkyl chain length and unsaturation in the fluid phase
12. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors
13. Inner but not outer membrane leaflets control the transition from glycosylphosphatidylinositol-anchored influenza hemagglutinin-induced hemifusion to full fusion
14. The exocytotic fusion pore and neurotransmitter release
15. Area/lipid of bilayer from NMR
16. The exocytotic fusion pore modeled as a lipidic pore
17. Hydrogen bonding of water to phosphatidylcholine in the membrane as studied by a molecular dynamics simulation: Location, geometry, and lipid-lipid bridging via hydrogen-bonded water
18. Charge pairing of headgroups in phosphatidylcholine membranes: A molecular dynamics simulation study
19. Fluid phase structure of EPC and DMPC bilayers
20. The synaptic SNARE complex is a parallel four-stranded helical bundle
21. Fusion of dimyristoyllecithin vesicles as studied by proton magnetic resonance spectroscopy
22. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysohosphatidic acid
23. The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance
24. Membrane-membrane interactions via intermediates in lamellar-to-inverted hexagonal phase transitions
25. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
26. Quasielastic neutron scattering measurement of fast local translational diffusion of lipid molecules in phospholipid bilayers
27. Molecular dynamics generation of nonarbitrary membrane models reveals lipid orientational correlations
28. Gramicidin A-induced fusion of large unilamellar dioleoylphosphatidylcholine vesicles and its relation to the induction of type II nonbilayer structures
29. Development of MD engine: High-speed accelerator with parallel processor design for molecular dynamics simulations
30. 2H-NMR studies of phospholipids differing in headgroup structure and chain length
31. Structural basis for membrane fusion by enveloped viruses
32. Atomic structure of the ectodomain from HIV-1 gp41
33. Membrane fusion
34. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution
35. Polymercushioned bilayers. II. An investigation of interaction forces and fusion using the surface forces apparatus
36. Computer simulation of liquid/liquid interfaces. I. Theory and application to octane/water