Iron loading and large doses of intravenous ascorbic acid promote lipid peroxidation in whole serum in guinea pigs

British Journal of Nutrition

Volumn 85, Issue 6, 2001, Pages 681-687

  Kapsokefalou, Maria ^a,b   Miller, Dennis D ^a  

^a Department of Molecular Biology and Genetics   (United States)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

Ascorbic acid; Iron; Oxidation

Indexed keywords

ASCORBIC ACID; BLEOMYCIN; IRON; IRON DEXTRAN; LOW DENSITY LIPOPROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFERRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; BLOOD ANALYSIS; BODY WEIGHT; CATALYST; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGENERATIVE DISEASE; GUINEA PIG; IN VITRO STUDY; IRON BINDING CAPACITY; IRON KINETICS; IRON OVERLOAD; LIPID PEROXIDATION; LOADING TEST; MALE; NONHUMAN; PUNCTURE; SERUM; TRANSFERRIN BLOOD LEVEL;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0034949468     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/bjn2001319     Document Type: Article

References (36)

1. Dietary iron intake and risk of coronary disease among men
2. Sources of iron for lipid peroxidation in biological systems
3. A possible mechanism for initiation of lipid peroxidation by ascorbate in rat liver microsomes
4. Effects of high level of vitamin C on tissue oxidant status of guinea pigs
5. Serum iron level, coronary artery disease, and all-cause mortality in older men and women
6. In vitro lipid peroxidation of human serum catalyzed by cupric ion: Antioxidant rather than prooxidant role of ascorbate
7. Effect of antioxidants on lipid peroxidation in iron-loaded guinea pigs
8. The role of lipid peroxidation and antioxidants in oxidative modification of LDL
9. Ascorbate is an outstanding antioxidant in human blood plasma
10. Iron overloading phenomena in animals
11. Effect of ferritin-containing fractions with different iron loading on lipid peroxidation
12. Iron complexes and their reactivity in the bleomycin assay for radical-promoting loosely-bound iron
13. Radical promoting loosely bound iron in biological fluids and the bleomycin assay
14. Lipid peroxidation: Some problems and concepts
15. Lipid peroxidation: Its mechanism, measurement, and significance
16. Viewpoint. Does mega-C do more good than harm, or more harm than good?
17. Antioxidant activity of ceruloplasmin in muscle membrane and in situ lipid peroxidation
18. The effect of vitamin C on in vivo lipid peroxidation in guinea pigs as measured by pentane and ethane production
19. Iron status and coronary heart disease: Negative findings from the NHANES I epidemiologic follow-up study
20. Errors in instrumental analysis; regression and correlation
21. Redox cycling of iron and lipid peroxidation
22. The role of iron in ferritin- and haemosiderin-mediated lipid peroxidation in liposomes
23. Low density lipoprotein rich in oleic acid is protected against oxidative modification: Implications for dietary prevention of atherosclerosis
24. The guinea pig
25. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans
26. Body iron stores, dietary iron intake and coronary heart disease mortality
27. Dietary supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins
28. High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men
29. Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice
30. Shortcut and nonparametric methods
31. Beyond cholesterol: Modifications of low density lipoprotein that increase its atherogenicity
32. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
33. The iron paradigm of ischemic heart disease
34. Association between body iron stores and the risk of acute myocardial infarction in men
35. Dietary iron and coronary heart disease risk: A study from Greece
36. Interaction of α-tocopherol with iron: Antioxidant and prooxidant effects of α-tocopherol in the oxidation of lipids in aqueous dispersions in the presence or iron