Studies on stress dispersion in tablets III. Suppression of fracture of coated film by an excipient during the preparation of tablets containing coated particles

S.T.P. Pharma Sciences

Volumn 11, Issue 3, 2001, Pages 221-227

  Yuasa, H ^a   Takashima, Y ^a   Omata, T ^a   Kanaya, Y ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Compression; Compression energy; Enteric coating; Eudragit L30D55; Excipients; Film fracture; Stress dispersion; Tablets

Indexed keywords

ACETYLSALICYLIC ACID; CALCIUM SILICATE; EUDRAGIT; EXCIPIENT; FLORITE RE; STARCH;

ARTICLE; COATED PARTICLE; COMPRESSION; DRUG RELEASE; FILM COATING; POROSITY; TABLET FORMULATION; TABLET MANUFACTURE; TENSILE STRENGTH;

EID: 0034948965     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Studies on internal structure of tablets. III. Manufacturing of tablets containing microcapsules
2. Studies on internal structure of tablets. VI. Stress dispersion in tablets by excipients
3. Analysis of the stress and strain distributions in the compressed powder in the limiting equilibrium state specified by the Mohr criterion theory and measurements of mechanical properties
4. Estimation of stress distribution in the convex type tablet using specific enzyme activity as a parameter
5. Influence of additives on the survival of lactic-acid bacteria in tabletting
6. Compression of microcapsules. II. Effect of excipients and pressure on physical properties
7. Compression of enteric-coated pellets to disintegrating tablets
8. Release of drug from suspended and tabletted microcapsules. I. Effect of excipients and pressure on drug release
9. Damage of microcapsule wall during compression
10. Tabletting of coated particles. I. Small particle size chitosan as an agent protecting coating membrane from mechanical damage of compression force
11. Tabletting of coated particles. II. Influence of particle size of pharmaceutical additives on protection of coating membrane from mechanical damage during compression process
12. Effect of different excipients on the tabletting of coated particles
13. Effect of superdisintegrant on antigen release from enteric-coated antigen microspheres
14. Development of cellulose derivatives as novel enteric coating agents soluble at pH 3.5-4.5 and higher
15. Density-pressure relationships in powder compaction
16. An analysis of powder compaction phenomena
17. Changes in volume and compression energy upon compression of calcium silicate tablets
18. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity
19. Effects of internal structure of the tablet on its mechanical strength
20. Studies on internal structure of tablets. II. Effect of the critical disintegrator amount on the internal structure of tablets
21. Plastic flow during compression of directly compressible fillers and its effect on tablet strength