A majority of fragile X males with methylated, full mutation alleles have significant levels of FMR1 messenger RNA

Journal of Medical Genetics

Volumn 38, Issue 7, 2001, Pages 453-456

  Tassone, F ^a   Hagerman, R J ^a,b   Taylor, A K ^c   Hagerman, P J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Kimball Genetics Inc   (United States)

Author keywords

Gene silencing; Neurodevelopment; Quantitative RT PCR; Trinucleotide repeat

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; GENE PRODUCT; MESSENGER RNA; UNCLASSIFIED DRUG;

ALLELISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME ACTIVITY; FLUORESCENCE; FRAGILE X SYNDROME; GENE MUTATION; GENE SILENCING; HUMAN; IMMUNOCYTOCHEMISTRY; MALE; METHYLATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

EID: 0034945678     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.38.7.453     Document Type: Article

References (19)

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6. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization
7. Real time quantitative PCR
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13. Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1
14. Instability of the CGG repeat and expression of the FMR1 protein in a male fragile X patient with a lung tumor
15. Transcription of the FMR1 gene in individuals with fragile X syndrome
16. Mitotic stability of fragile X mutations in differentiated cells indicates early post-conceptional trinucleotide repeat expansion
17. Heterogeneity of DM kinase repeat expansion in different fetal tissues and further expansion during cell proliferation in vitro: Evidence for a casual involvement of methyl-directed DNA mismatch repair in triplet repeat stability
18. Interactions of the transcription factors USF1, USF2 and alpha-Pal/Nrf-1 at the FMR1 promoter: Implications for fragile X mental retardation syndrome
19. Translational suppression by trinucleotide repeat expansion at FMR1