Contradistinction between doxorubicin and epirubicin: In-vivo metabolism, pharmacokinetics and toxicodynamics after single- and multiple-dosing in rats

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 7, 2001, Pages 987-997

  Ramanathan Girish, S ^a   Boroujerdi, M ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADRIAMYCINONE; ALCOHOL; BIOLOGICAL MARKER; DOXORUBICIN; DRUG METABOLITE; EPIRUBICIN; HEMOGLOBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BLOOD CELL; BLOOD CELL COUNT; CARDIOTOXICITY; CELL INTERACTION; COMPARATIVE STUDY; COMPARATIVE TOXICOLOGY; COMPARTMENT MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION FUNCTION; CURVE FITTING; DOSE RESPONSE; DRUG BILE LEVEL; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG MONITORING; DRUG URINE LEVEL; ENZYME ANALYSIS; ERYTHROCYTE; HEART MUSCLE; IN VIVO STUDY; INJECTION; LINEAR SYSTEM; MALE; MEAN RESIDENCE TIME; NONHUMAN; PHARMACODYNAMICS; PLASMA CLEARANCE; RAT; SARCOPLASMIC RETICULUM; TOXICOLOGICAL PARAMETERS; WESTERN BLOTTING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BILE; CALCIUM-TRANSPORTING ATPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG ADMINISTRATION SCHEDULE; EPIRUBICIN; INJECTIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 0034944458     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011776234     Document Type: Article

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