Cathepsin K in aseptic hip prosthesis loosening: Expression in osteoclasts without polyethylene wear particles

Journal of Rheumatology

Volumn 28, Issue 7, 2001, Pages 1615-1619

  Hansen, T ^a   Otto, M ^a   Gaumann, A ^a   Eckardt, A ^a   Petrow, P K ^a   Delank, K S ^a   Kirkpatrick, C J ^a   Kriegsmann, J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Aseptic hip prosthesis loosening; Cathepsin K; Osteoclasts; Polyethylene particles

Indexed keywords

CATHEPSIN K; CD68 ANTIGEN; CYSTEINE PROTEINASE; POLYETHYLENE;

ARTICLE; BONE DESTRUCTION; BONE MATRIX; CLINICAL ARTICLE; FEMALE; HIP PROSTHESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMPLANT; MALE; OSTEOCLAST; PRIORITY JOURNAL; PROSTHESIS LOOSENING; STAINING;

ACETABULUM; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CATHEPSINS; FEMALE; HIP PROSTHESIS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; OSTEOCLASTS; POLYETHYLENE; PROSTHESIS FAILURE;

EID: 0034941778     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. The biology of the loosening of hip implants
2. Size of metallic and polyethylene debris particles in failed cemented total hip replacements
3. Mediators of bone resorption around implants
4. Human arthroplasty derived macrophages differentiate into osteoclastic bone resorbing cells
5. Production of cytokines around loosened cemented acetabular components
6. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis
7. High cathepsin B activity in arthroplasty interface membranes
8. Production of matrix metalloproteinases at the bone-implant interface in loose total hip replacements
9. Immunohistochemical analysis of matrix proteolytic enzymes in the periprosthetic tissue in the patients with loosening prostheses
10. Expression of gelatinase A and its activator MT1-MMP in the inflammatory periprosthetic response to polyethylene
11. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts
12. Proteolytic activity of human osteoclast cathepsin K
13. The collagenolytic activity of cathepsin K is unique among mammalian proteinases
14. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
15. Application of Nile red, a fluorescent hydrophobic probe, for the detection of neutral lipid deposits in tissue sections: Comparison with oil red O
16. Histologic identification of polyethylene wear debris using oil red O stain
17. Migration of metal and polyethylene particles from articular prostheses may generate lymphadenopathy with histiocytosis
18. Postarthroplasty histiocytic lymphadenopathy in gynecologic oncology patients
19. Cathepsin B and its endogenous inhibitor cystatin C in rheumatoid arthritis synovium
20. Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction
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23. Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry
24. Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur
25. The characterization of macrophages and osteoclasts in tissues harvested from revised total hip prostheses
26. Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts
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28. Composition and morphology of wear debris in failed uncemented total hip replacements
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30. Biomaterial particle phagocytosis by bone-resorbing osteoclasts