Mutation analysis of the CHK2 gene in families with hereditary breast cancer

British Journal of Cancer

Volumn 85, Issue 2, 2001, Pages 209-212

  Allinen, M ^a   Huusko, P ^a   Mantyniemi S ^b   Launonen, V ^c   Winqvist, R ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

CHK2 mutations; Hereditary breast cancer; Li Fraumeni like syndrome

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CHECKPOINT KINASE 2; ONCOPROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; FAMILIAL CANCER; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; PEDIGREE; PRIORITY JOURNAL;

BREAST NEOPLASMS; COHORT STUDIES; FEMALE; GERM-LINE MUTATION; HUMANS; MALE; PEDIGREE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

EID: 0034940858     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1858     Document Type: Article

References (25)

1. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
2. Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families
3. How many more breast cancer predisposition genes are there?
4. Third international workshop on collaborative interdisciplinary studies of p53 and other predisposing genes in Li-Fraumeni syndrome
5. Follow-up study of twenty-four families with Li-Fraumeni syndrome
6. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
7. Evidence of founder mutations in Finnish BRCA1 and BRCA2 families
8. Germ-line TP53 mutations in Finnish cancer families exhibiting features of the Li-Fraumeni syndrome and negative for BRCA1 and BRCA2
9. Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus
10. Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: Comparison with denaturing gradient gel electrophoresis and nucleotide sequencing
11. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
12. Environmental and heritable factors in the causation of cancer
13. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
14. The p53 pathway
15. Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites
16. Screening hCHK2 for mutations
17. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
18. Low porpotion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: Evidence for additional susceptibility genes
19. A low porpotion of BRCA2 mutations in Finnish breast cancer families
20. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
21. Indentification of the breast cancer susceptibility gene BRCA2
22. Characterization of tumor-associated Chk2 mutations