Semenogelin, the main protein of semen coagulum, inhibits human sperm capacitation by interfering with the superoxide anion generated during this process

Journal of Andrology

Volumn 22, Issue 4, 2001, Pages 672-679

  De Lamirande, E ^a   Yoshida, K ^a   Yoshiike, M ^a   Iwamoto, T ^a   Gagnon, C ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Prostate specific antigen; Protein degradation; Protein tyrosine phosphorylation; Reactive oxygen species; Ribonuclease; Seminal plasma motility inhibitor

Indexed keywords

PEPTIDE; PROSTATE SPECIFIC ANTIGEN; PROTEIN; PROTEINASE; REACTIVE OXYGEN METABOLITE; RIBONUCLEASE; SEMENOGELIN; SUPEROXIDE; TYROSINE; UNCLASSIFIED DRUG; XANTHINE; XANTHINE OXIDASE;

ARTICLE; CHEMOLUMINESCENCE; DOSE RESPONSE; HUMAN; HUMAN CELL; MALE FERTILITY; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SEMINAL VESICLE; SPERM; SPERMATOZOON CAPACITATION; SPERMATOZOON MOTILITY;

HUMANS; MALE; PHOSPHORYLATION; PROSTATE-SPECIFIC ANTIGEN; RIBONUCLEASES; SEMINAL VESICLE SECRETORY PROTEINS; SPERM CAPACITATION; SPERMATOZOA; SUPEROXIDES; TYROSINE; XANTHINE; XANTHINE OXIDASE;

EID: 0034940268     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1939-4640.2001.tb02228.x     Document Type: Article

References (25)

1. A novel signal transduction cascade in capacitating human spermatozoa characterized by redox-regulated cAMP-mediated induction of tyrosine phosphorylation
2. Role of zinc in hamster sperm capacitation
3. Zinc effects on mouse spermatozoa and in vitro fertilization
4. The culture of mouse embryos in vitro
5. Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunochemistry
6. Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: Identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation
7. Premature capacitation of bovine spermatozoa is initiated by cryopreservation
8. Human seminal plasma prevents sperm from becoming acrosomally responsive to the agonist progesterone: Cholesterol is the major inhibitor
9. Two simple: Methods for detecting the acrosome reaction of human sperm
10. Inverse relationship between the induction of human sperm capacitation and spontaneous acrosome reaction by various biological fluids and the superoxide scavenging capacity of these fluids
11. Human sperm hyperactivation in whole semen and its association with low superoxide scavenging capacity in seminal plasma
12. Human sperm hyperactivation and capacitation as parts of an oxidative process
13. Capacitation-associated production of superoxide anion by human spermatozoa
14. Human sperm capacitation induced by biological fluids and progesterone but not by NADH or NADPH, is associated with the production of superoxide anion
15. Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization
16. Major proteins of seminal plasma exhibit novel interactions with phospholipids
17. Purification and characterization of a sperm motility inhibitor in human seminal plasma
18. A human seminal plasma protein blocks the motility of human spermatozoa
19. Important parameters in semi-dry electrophoresis transfer
20. Human X- and Y-bearing sperm differ in cell surface sialic acid content
21. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
22. Phosphatidylcholine-binding proteins from the seminal plasma of different species share antigic determinants with the major protein of bovine seminal plasma
23. cAMP-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility
24. Regulation of protein tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivatives
25. Interaction between Ca2+, cyclic 3′, 5′ adenosine monophosphate, the superoxide anion, and tyrosine