Nipecotic acid directly activates GABAA-like ion channels

British Journal of Pharmacology

Volumn 133, Issue 5, 2001, Pages 673-678

  Barrett Jolley, R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

GABA; Mediocellular; Nipecotic acid; Paraventricular; Parvocellular; PVN; Single channel

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID DERIVATIVE; BICUCULLINE; CHLORIDE CHANNEL; CHLORIDE ION; ION CHANNEL; NIPECOTIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; GABAERGIC TRANSMISSION; MEMBRANE CONDUCTANCE; MEMBRANE CURRENT; MEMBRANE STEADY POTENTIAL; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; THALAMUS MIDLINE NUCLEUS;

EID: 0034939713     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704128     Document Type: Article

References (37)

1. Tiagabine-A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of epilepsy
2. The role of GABA in modulating the Xenopus electroretinogram
3. Nitric oxide regulates NMDA-driven GABAergic inputs to type I neurones of the rat paraventricular nucleus
4. Kinetic analysis of the inhibitory effect of glibenclamide on K(ATP) channels of mammalian skeletal muscle
5. Characterisation of K(ATP) channels in intact mammalian skeletal muscle fibres
6. Measurement of voltage-gated potassium currents in identified spinally-projecting sympathetic neurones of the paraventricular nucleus
7. Monotherapy trials of new antiepileptic drugs
8. Physiological mapping of local inhibitory inputs to the hypothalamic paraventricular nucleus
9. Gabaergic inhibition of hypertonic saline-induced vasopressin-dependent hypertension
10. Influence of neuroglial transport on the action of gamma-aminobutyric acid on mammalian ganglion cells
11. Ions required for the electrogenic transport of GABA by horizontal cells of the catfish retina
12. Channel behavior in a gamma-aminobutyrate transporter
13. Neurotransmitter-mediated control of neuronal firing in the red nucleus of the rat: Reciprocal modulation between noradrenaline and GABA
14. A suite of programs for acquisition and analysis of voltage-clamp and patch-clamp data developed using the Axobasic library
15. Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells
16. Selective inhibitors of glial GABA uptake: Synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues
17. Endogenous GABA attenuates CNS white-matter dysfunction following anoxia
18. Endogenous GABA potentiates the potassium-induced release of opamine in striatum of the freely moving rat: A microdialysis study
19. The role of amygdala and hypothalamus in GABA(A) antagonist bicuculline-induced cardiovascular responses in conscious rats
20. GABA and glutamate mediate rapid neurotransmission from suprachiasmatic nucleus to hypothalamic paraventricular nucleus in rat
21. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro
22. Inhibition of the uptake of GABA and related amino acids in rat brain slices by the optical isomers of nipecotic acid
23. Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds
24. Riluzole, a novel antiglutamate, blocks GABA uptake by striatal synaptosomes
25. Hemodynamic-responses to paraventricular nucleus disinhibition with bicuculline in conscious rats
26. A tonic gamma-aminobutyric acid-mediated inhibition of cholinergic amacrine cells in rabbit
27. Neurotransmitter transporters in the central nervous system
28. Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake
29. Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro
30. Use of gamma-aminobutyric acid (GABA)-transaminase inhibitors and a GABA uptake inhibitor to investigate the influence of GABA neurons on dopamine-containing amacrine cells of the rat retina
31. Development and role of GABA(A) receptor-mediated synaptic potentials during swimming in postembryonic Xenopus laevis tadpoles
32. Cloning, expression, and localization of a mouse retinal gamma-aminobutyric acid transporter
33. Data transformations for improved display and fitting of single-channel dwell time histograms
34. GABA receptor mechanisms in the central nervous system
35. A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor
36. Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nuclei
37. Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: Role of GABA