Norepinephrine induces action potential prolongation and early afterdepolarizations in ventricular myocytes isolated from human end-stage failing hearts

European Heart Journal

Volumn 22, Issue 11, 2001, Pages 955-963

  Veldkamp, M W ^a   Verkerk, A O ^a   Van Ginneken, A C G ^a   Baartscheer, A ^a   Schumacher, C ^a   De Jonge, N ^b   De Bakker, J M T ^b,c   Opthof, Tobias ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Action potential duration; Arrhythmias; Heart failure; Myocytes; Norepinephrine

Indexed keywords

CALCIUM ION; NORADRENALIN;

ARRHYTHMOGENESIS; ARTICLE; CELL ISOLATION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DISEASE SEVERITY; HEART AFTERLOAD; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART DILATATION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; NORADRENALIN RELEASE; PATCH CLAMP; PRIORITY JOURNAL;

ACTION POTENTIALS; ADRENERGIC ALPHA-AGONISTS; CALCIUM CHANNELS; DELAYED-ACTION PREPARATIONS; HEART FAILURE, CONGESTIVE; HEART VENTRICLES; HUMANS; ION CHANNELS; MYOCARDIUM; NOREPINEPHRINE;

EID: 0034936504     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1053/euhj.2000.2499     Document Type: Article

References (48)

1. Hypertension and sudden death: Increased ventricular ectopic activity in left ventricular hypertrophy
2. Risk of ventricular arrhythmias in left ventricular hypertrophy: The Framingham Heart Study
3. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
4. Neurohormonal mechanisms involved in congestive heart failure
5. Development of arrhythmias in the patient with congestive heart failure: Pathophysiology, prevalence and prognosis
6. Factors causing arrhythmias in chronic congestive heart failure
7. On the mechanism of β-adrenergic regulation of the Ca channel in the guinea pig heart
8. K) in guinea pig ventricular myocytes
9. Adrenergic modulation of the transient outward current in isolated canine Purkinje cells
10. Autonomic regulation of a chloride current in heart
11. "Experimental Arrhythmia Research" of the Working Group on arrhythmias of the European Society of cardiology. The role of basic arrhythmia research: The continued need for experiments in the intact heart and organism
12. Adrenoceptor-mediated changes of action potential and force of contraction in human isolated ventricular heart muscle
13. Electrical properties and response to noradrenaline of individual heart cells isolated from human ventricular tissue
14. Cellular electrophysiology in cardiac hypertrophy and failure
15. β-Adrenergic pathways in nonfailing and failing human ventricular myocardium
16. Delayed rectifier channels in human ventricular myocytes
17. The cytoplasmic free energy of ATP hydrolysis in isolated rod-shaped rat ventricular myocytes
18. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
19. K, by cadmium in cat ventricular myocytes
20. Cardiac action potential and inotropic effect of noradrenaline and calcium
21. Adrenergic induction of delayed afterdepolarizations in ventricular myocardial cells: Induction and modulation
22. Effects of constant inward current and norepinephrine on the electrophysiology of isolated rabbit ventricular myocytes
23. The effects of heart rate, action of autonomic nerves and chemical mediators on cardiac excitability
24. The effect of drugs on the cardiac membrane potentials in the rabbit
25. Effect of epinephrine on the duration of action potential of papillary muscles
26. Effects of selective α1-, α2-, β1- and β2-adrenoceptor stimulation on potentials and contractions in the rabbit heart
27. Dispersion of refractoriness in normal and ischaemic canine ventricle: Effects of sympathetic stimulation
28. Injury current modulates afterdepolarizations in single human ventricular cells
29. Electrophysiology and pharmacology of cardiac arrhythmias IX. Cardiac electrophysiologic effects of beta adrenergic receptor stimulation and blockade. Part C
30. The effect of propranolol (Inderal) on the electrocardiogram of normal subjects
31. The electrophysiology of propranolol in man
32. Effects of acute and chronic beta-receptor blockade on ventricular repolarisation in man
33. Electrophysiologic actions of high plasma concentrations of propranolol in human subjects
34. Effects of propranolol on ventricular repolarization in man
35. QT dispersion: Time for an obituary?
36. Slow inward current in aggregates of neonatal rat heart cells and its contribution to the steady state current-voltage relationship
37. Slow inward current in single cells isolated from adult human ventricles
38. Calcium currents in diseased human cardiac cells
39. L-type calcium currents of human myocytes from ventricle of non-failing and failing hearts and from atrium
40. Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes
41. Effects of isoproterenol and caffeine on calcium transients and action potentials in human ventricular myocytes
42. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle
43. Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines
44. Early afterdepolarizations: Mechanism of induction and block
45. Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence
46. Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension
47. Gap junctions in cardiovascular disease
48. Afterdepolarizations and triggered activity