A new insect neurotoxin AngP1 with analgesic effect from the scorpion Buthus martensii Karsch: Purification and characterization

Journal of Peptide Research

Volumn 58, Issue 1, 2001, Pages 27-35

  Guan, R J ^a   Wang, M ^a   Wang, D ^a   Wang, Da Cheng ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Analgesic effect; Characterization; Purification; Scorpion toxin

Indexed keywords

BMK ANGP1; INSECT VENOM; NEUROTOXIN; SCORPION VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; BUTHUS MARTENSII; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; ISOELECTRIC POINT; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SCORPION;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; CIRCULAR DICHROISM; CRYSTALLIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; INSECTICIDES; MALE; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NEUROTOXINS; ORGANIC CHEMICALS; SCORPION VENOMS; SCORPIONS; SEQUENCE ANALYSIS, PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TOXICITY TESTS;

ANIMALIA; BUTHUS; INSECTA; INVERTEBRATA; MAMMALIA; MESOBUTHUS MARTENSII; SCORPIONES;

EID: 0034935647     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00869.x     Document Type: Article

References (20)

1. Insect specific neurotoxins from scorpion venom that affect sodium current inactivation
2. Reconstitution of high-affinity binding of a beta-scorpion toxin to neurotoxin receptor site 4 on purified sodium channels
3. Two neurotoxins (BmK I and BmK II) from the venom of the scorpion Buthus martensii Karsch: Purification, amino acid sequence and assessment of specific activity
4. Purification and sequence determination of a new neutral mammalian neurotoxin from the scorpion Buthus martensii Karsch
5. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes
6. Scorpion neurotoxins: Effects and mechanisms
7. +-channel-blocking toxins of the scorpion Centruroides noxius Hoffmann
8. Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquesrtiatus
9. The genomic region encoding toxin gamma from the scorpion Tityus serrulatus contains an intron
10. Purification and N-terminal partial sequence of anti-epilepsy peptide from venom of the scorpion BmK
11. Analgesic effect of the venom of scorpion Buthus martensii Karsch
12. Molecular characterization of a new excitatory insect neurotoxin with an analgesic effect on mice from the scorpion BmK
13. The assessment of and the problems involved in the experimental evaluation of narcotic analgesics
14. An excitatory and a depressant insect toxin from scorpion venom both affect sodium conductance and possess a common binding site
15. A series of bioactivity-variant neurotoxins from scorpion Buthus martensii Karsch: Purification, crystallization and crystallographic analysis
16. 1H nuclear magnetic resonance study of AaH IT, an anti-insect toxin from the scorpion Androctonus australis Hector. Sequential resonance assignments and folding of the polypeptide chain
17. An excitatory scorpion toxin with a distinctive feature: An additional α-helix at the C terminus and its implications for interaction with insect sodium channels
18. Covalent structure of the insect toxin of the North Africa scorpion AaH
19. Neurotoxins active on insects: Amino acid sequences, chemical modifications, and secondary structure estimation by circular dichroism of toxins from the scorpion Androctonus australis Hector