Quantitative analysis of BRCA1 and BRCA2 mRNA expression in sporadic breast carcinomas and its relationship with clinicopathological characteristics

Japanese Journal of Cancer Research

Volumn 92, Issue 6, 2001, Pages 624-630

  Egawa, C ^a   Miyoshi, Y ^a   Taguchi, T ^a   Tamaki, Y ^a   Noguchi, S ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

BRCA1; BRCA2; Breast cancer; mRNA expression; RT PCR

Indexed keywords

BETA GLUCURONIDASE; BRCA1 PROTEIN; BRCA2 PROTEIN; ESTROGEN RECEPTOR; MESSENGER RNA; PROGESTERONE RECEPTOR;

ADULT; AGED; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GRADING; CANCER GROWTH; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE; MAJOR CLINICAL STUDY; MENSTRUATION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR VOLUME;

EID: 0034935366     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01140.x     Document Type: Article

References (35)

1. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
2. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
3. Sequence analysis of BRCA1 and BRCA2: Correlation of mutations with family history and ovarian cancer risk
4. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer
5. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium
6. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews
7. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families
8. Growth retardation and tumour inhibition by BRCA1
9. Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer
10. A somatic truncating mutation in BRCA2 in a sporadic breast tumor
11. BRCA2 mutations in primary breast and ovarian cancers
12. Mutation analysis in the BRCA2 gene in primary breast cancers
13. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
14. Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells
15. Overexpression of BRCA2 gene in sporadic breast tumours
16. Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers
17. BRCA1 expression levels predict distant metastasis of sporadic breast cancers
18. Germline BRCA1 mutations and loss of the wild-type allele in tumors from families with early onset breast and ovarian cancer
19. Clinicopathologic analysis of BRCA1- or BRCA2-associated hereditary breast carcinoma in Japanese women
20. Germ line mutation at BRCA1 affects the histoprognostic grade in hereditary breast cancer
21. Truncation at conserved terminal regions of BRCA1 protein is associated with highly proliferating hereditary breast cancers
22. Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers
23. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas
24. Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases
25. Acceleration of chromosomal instability by loss of BRCA1 expression and p53 abnormality in sporadic breast cancers
26. Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13
27. Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage
28. BRCA2 hereditary breast cancer pathophenotype
29. Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells
30. Cell cycle control of BRCA2
31. BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen
32. Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers
33. Quantification of BRCA1 protein in sporadic breast carcinoma with or without loss of heterozygosity of the BRCA1 gene
34. BRCA2 protein expression in sporadic breast carcinoma with or without allelic loss of BRCA2
35. Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer