Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis

Biomedical Chromatography

Volumn 15, Issue 4, 2001, Pages 248-251

  Li, Famei ^a   Yu, Lining ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CAPILLARY ELECTROPHORESIS; ELECTROLYTES; HISTOLOGY; RATS;

CAPILLARY-ZONE ELECTROPHORESIS; INTERNAL STANDARDS; MALEATE; METHANOL-WATER; PHOSPHATE BUFFERS; RAT PLASMA; RAT TISSUE; SIMPLE++; SUPERNATANTS; TISSUE HOMOGENATES;

TISSUE;

ACETONITRILE; BUFFER; EPHEDRINE; METHANOL; NITROGEN; PHOSPHATE; TRIMEBUTINE MALEATE; WATER;

ACCURACY; ANALYTIC METHOD; ANALYTICAL ERROR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CENTRIFUGATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TISSUE LEVEL; FEMALE; HEART; KIDNEY PARENCHYMA; LIVER; LUNG PARENCHYMA; MALE; NONHUMAN; PH; RAT; SPLEEN; TISSUE DISTRIBUTION; TISSUE HOMOGENATE;

EID: 0034932739     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.52     Document Type: Article

References (15)

1. Ion-pair formation of Bi (III)-iodide with some nitrogenous drugs and its application to pharmaceutical preparations
2. Local actions of trimebutine maleate in canine small intestine
3. The effect of trimebutine maleate on colonic motility and controlled comparative trials in irritable bowel syndrome
4. Effect of trimebutine maleate (TM-906) on electrical and mechanical activities of smooth muscles of the guinea pig stomach
5. Metabolism of trimebutine maleate, a gastrointestinal tract motility regulator in rats and mice: Characterization and quantification of metabolites in urine, bile and plasma
6. A clinical trial of trimebutine (Mebutine) in spastic colon
7. Qualitative organic analysis. I. Identification of drugs by principal components analysis of standard thin-layer chromatographic data in four eluent systems
8. Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells
9. Physicochemical properties and stability of trimebutine maleate
10. Effects of trimebutine maleate on the gastrointestinal motility in conscious dogs
11. Effect of trimebutine maleate (TM-906) on spontaneous contraction of isolated guinea pig colon
12. Dual effects of trimebutine on electrical responses of gastric smooth muscles in the rat
13. Effects of trimebutine maleate on interdigestive motility of the stomach and small intestine in conscious dogs
14. Biological fate of trimebutine maleate (1) absorption, distribution and excretion in rats, mice and dogs
15. Capillary zone electrophoresis for the determination of trimebutine maleate in capsules