New approaches to dissect degeneracy and specificity in T cell antigen recognition

Journal of Molecular Medicine

Volumn 79, Issue 7, 2001, Pages 358-367

  Jacobsen, Marc ^a   Cepok, Sabine ^a   Oertel, Wolfgang H ^a   Sommer, Norbert ^a   Hemmer, Bernhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Autoimmunity; Degeneracy; Peptide libraries; T cell receptor; T cell recognition

Indexed keywords

PEPTIDE LIBRARY; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; IMMUNE SYSTEM; MOLECULAR BIOLOGY; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; HUMANS; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; MODELS, BIOLOGICAL; PEPTIDE LIBRARY; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0034927719     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090100230     Document Type: Review

References (77)

1. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
2. T-cell antigen receptor genes and T-cell recognition
3. Development and selection of T cells: Facts and puzzles
4. The immunological synapse: A molecular machine controlling T cell activation
5. From TCR engagement to T cell activation: A kinetic view of T cell behavior
6. Three-dimensional segregation of supramolecular activation clusters in T cells
7. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands
8. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
9. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
10. T cell antigen receptor signal transduction
11. Atomic structure of a human MHC molecule presenting an influenza virus peptide
12. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
13. Structures of an MHC class II molecule with covalently bound single peptides
14. MHC ligands and peptide motifs: First listing
15. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single chain transgenics
16. The specificity and orientation of a TCR to its peptide-MHC class II ligands
17. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
18. An α/β T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex
19. Alanine scanning mutagenesis of an alphabeta T cell receptor: Mapping the energy of antigen recognition
20. The crystal structure of a T cell receptor in complex with peptide and MHC class II
21. Structural basis of T cell recognition
22. Essential flexibility in the T-cell recognition of antigen
23. Probing degeneracy in T-cell recognition using peptide combinatorial libraries
24. A very high level of crossreactivity is an essential feature of the T cell receptor
25. Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
26. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
27. Complete dissection of the Hb (64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas
28. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor
29. Induction of T-cell anergy by altered T cell receptor ligand on live antigen-presenting cells
30. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells
31. Partial T cell signaling: Altered phospho-ξ and lack of zap70 recruitment in APL-induced T cell anergy
32. Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
33. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes
34. The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection
35. Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade
36. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides
37. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
38. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production
39. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
40. Specific T cell recognition of minimally homologous peptides: Evidence for endogenous ligands
41. Cutting edge: Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology
42. A differential-avidity model for T-cell selection
43. Permessive recognition during positive selection
44. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide
45. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span
46. Differential requirements for survival and proliferation of CD8 naive or memory T cells
47. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
48. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
49. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
50. A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein
51. CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma
52. Direct identification of tumor-associated peptide antigens
53. Gene isolation with human T lymphocyte probes. Isolation of a gene that expresses an epitope recognized by T cells specific for Mycobacterium bovis BCG and pathogenic mycobacteria
54. Identification of a CD4+ T cell stimulating antigen of pathogenic bacteria by expression cloning
55. T-cell epitope analysis using subtracted expression libraries (TEASEL): Application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient
56. The identification of CD4+ T cell epitopes with dedicated synthetic peptide libraries
57. Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries
58. A new hybrid resin for stepwise screening of peptide libraries combined with single bead Edman sequencing
59. Antigen arrays in T cell immunology
60. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
61. Acetalins: Opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries
62. Investigation of antigen-antibody interactions using a soluble nonsupport-bound synthetic decapeptide library composed of four trillion sequences
63. Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries
64. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries
65. The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells
66. Exploring immunological specificity using synthetic peptide combinatorial libraries
67. New ligands binding to the human leukocyte antigen class II molecule DRB 1*0101 based on the activity pattern of an undecapeptide library
68. Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries
69. Specificity and degeneracy of minor histocompatibility antigen-specific MHC restricted CTL
70. Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone
71. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone
72. Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency
73. Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes
74. Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries
75. Immunological memory and protective immunity: Understanding their relation
76. Rapid identification of local T cell expansion in inflammatory organ diseases by flow cytometric T cell receptor V beta analysis
77. Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease