Late preconditioning is blocked by racemic ketamine, but not by S(+)-ketamine

Anesthesia and Analgesia

Volumn 93, Issue 2, 2001, Pages 265-270

  Müllenheim, Jost ^a   Rulands, Ralf ^b   Wietschorke, Thomas ^b   Frädorf, Jan ^d   Preckel, Benedikt ^a   Schlack, Wolfgang ^a,c  

^a Inst Klinische Anaesthesiologie   (Germany)

^b Institut für Herz und Kreislaufphysiologie   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART OUTPUT; HEART PROTECTION; HEMODYNAMIC PARAMETERS; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SYSTOLIC BLOOD PRESSURE;

EID: 0034926948     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200108000-00005     Document Type: Article

References (25)

1. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
2. Human ventricular myocytes in vitro exhibit both early and delayed preconditioning responses to simulated ischemia
3. The nitric oxide hypothesis of late preconditioning
4. Previous angina alters in-hospital outcome in TIMI 4
5. Effects of ketamine and its isomers on ischemic preconditioning in the isolated rat heart
6. Ketamine, but not S(+)-ketamine blocks ischemic preconditioning in rabbit hearts in vivo
7. ATP-channels in rabbit hearts
8. Ketamine inhibits nitric oxide synthase in lipopolysaccharide-treated rat alveolar macrophages
9. NF-kB activation is a possible mechanism for proinflammatory cytokines release in trauma patients
10. Xenon administration during early reperfusion reduces infarct size after regional ischemia in the rabbit heart in vivo
11. Ketamine infusions: Pharmacokinetics and clinical effects
12. Kinetics of ketamine and its metabolites in rabbits with normal and impaired renal function
13. Characterisation of the infarct-limiting effect of delayed preconditioning: Timecourse and dose-dependency studies in rabbit myocardium
14. Activation of mitochondrial ATP-dependent potassium channels by nitric oxide
15. Delayed ischemic preconditioning is mediated by opening of ATP-sensitive potassium channels in the rabbit heart
16. Anaesthetic agents decrease the activity of nitric oxide synthase from human polymorphonuclear leucocytes
17. Blockade of myocardial ATP-sensitive potassium channels by ketamine
18. Ketamine has stereospecific effects in the isolated perfused guinea pig heart
19. Ischemic preconditioning increases iNOS transcript levels in conscious rabbits via a nitric oxide-dependent mechanism
20. + channels
21. Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide
22. Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart
23. ATP-channels: Reduction of myocardial infarct size with an acute memory phase
24. Prior preconditioning by ischemia or sevoflurane improves cardiac work per oxygen use in isolated guinea pig hearts after global ischemia
25. Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits