A prospective multicenter trial to determine the incidence of transient neurologic symptoms after spinal anesthesia with phenylephrine added to 0.5% tetracaine

Hiroshima Journal of Medical Sciences

Volumn 50, Issue 2, 2001, Pages 47-51

  Maehara, Yasuhiro ^a   Kusunoki, Shinji ^a   Kawamoto, Masashi ^a   Yuge, Osafumi ^a   Okida, Motoichi ^b   Kinoshita, Hiroyuki ^c   Nakagawa, Itsuo ^d   Nakao, Masakazu ^e   Sasaki, Hiroshi ^f  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b Hiroshima Red Cross Atom Bomb S ^*  (Japan)

^c HIROSHIMA CITY ASA HOSPITAL   (Japan)

^d CHUGOKU ROSAI HOSPITAL   (Japan)

^e Chuden Hospital   (Japan)

^f Yoshida General Hospital   (Japan)

Author keywords

Phenylephrine; Spinal anesthesia; Transient neurologic symptoms

Indexed keywords

GLUCOSE; PHENYLEPHRINE; TETRACAINE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MIXTURE; ELECTIVE SURGERY; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PROSPECTIVE STUDY; SENSORY DYSFUNCTION; SPINAL ANESTHESIA; SURGICAL PATIENT;

ANESTHESIA, SPINAL; ANESTHETICS, LOCAL; DOUBLE-BLIND METHOD; FEMALE; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; JAPAN; MALE; MIDDLE AGED; NERVOUS SYSTEM DISEASES; PAIN; PHENYLEPHRINE; POSTOPERATIVE COMPLICATIONS; SURGICAL PROCEDURES, ELECTIVE; TETRACAINE; UROLOGIC SURGICAL PROCEDURES; VASOCONSTRICTOR AGENTS;

EID: 0034923937     PISSN: 00182052     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Bernards, C.M. and Kopacz, D.J. 1999. Effect of epinephrine on lidocaine clearance in vivo. Anesthesiology 91: 962-968.
2. Bonica, J.J., Backup, P.H. and Pratt, W.H. 1951. The use of vasoconstrictors to prolong spinal anesthesia. Anesthesiology 12: 431-441.
3. Concepcion, M., Maddi, R., Francis, D., Rocco, A.G., Murray, E. and Covino, B. G. 1984. Vasoconstrictors in spinal anesthesia with tetracaine -a comparison of epinephrine and phenylephrine. Anesth. Analg. 63: 134-138.
4. Denson, D.D., Turner, P.A., Bridenbaugh, P.O. and Thompson, G.A. 1984. Pharmacokinetics and neural blockade after subarachnoid lidocaine in the rhesus Monkey. III. Effects of phenylephrine. Anesth. Analg. 63: 129-133.
5. Gaumann, D., Forster, A., Griessen, M., Habre, W., Poinsot, O. and Santa, D.D. 1992. Comparison between clonidine and epinephrine admixture to lidocaine in brachial plexus block. Anesth. Analg. 75: 69-74.
6. Hampl, K.F., Schneider, M.C., Ummenhofer, W. and Drewe, J. 1995. Transient neurologic symptoms after spinal anesthesia. Anesth. Analg. 81: 1148-1153.
7. Hampl, K.F., Schneider, M.C., Thorin, D., Ummenhofer, W. and Drewe, J. 1995. Hyperosmolarity does not contribute to transient radicular irritation after spinal anesthesia with hyperbaric 5% lidocaine. Regional Anesthesia 20: 363-368.
8. Iselin-Chaves, I.A., Van Gessel, E.F., Donald, F.A., Forster, A. and Gamulin, Z. 1996. The effects of solution concentration and epinephrine on lateral distribution of hyperbaric tetracaine spinal anesthesia. Anesth. Analg. 83: 755-759.
9. Kito, K., Kato, H., Shibata, M., Adachi, T., Nakao, S. and Mori, K. 1998. The effect of varied doses of epinephrine on duration of lidocaine spinal anesthesia in the thoracic and lumbosacral dermatomes. Anesth. Analg. 86: 1018-1022.
10. Kozody, R., Swartz, J., Palahniuk, R.J., Biehl, D.R. and Wade, J.G. 1985. Spinal cord blood flow following subarachnoid lidocaine. Can. Anaesth. Soc. J. 32: 472-478.
11. Molnar, R.R., Davies, M.J., Scott, D.A., Silbert, B.S. and Mooney, P.H. 1997. Comparison of clonidine and epinephrine in lidocaine for cervical plexus block. Regional Anesthesia 22: 137-142.
12. Phillips, O.C., Ebner, H., Nelson, A.T. and Black, M.H. 1969. Neurologic complications following spinal anesthesia with lidocaine. Anesthesiology 30: 284-289.
13. Pollock, J. E., Neal, J.M., Stephenson, R.N. and Wiley, C.E. 1996. Prospective study of the incidence of transient radicular irritation in patients undergoing spinal anesthesia. Anesthesiology 84: 1361-1367.
14. Sakura, S., Sumi, M., Sakaguchi, Y., Saito, Y., Kosaka, Y. and Drasner, K. 1997. The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine. Anesthesiology 87: 771-778.
15. Salmela, L. and Aromaa, U. 1998. Transient radicular irritation after spinal anesthesia induced with hyperbaric solutions of cerebrospinal fluid-diluted lidocaine 50 mg/ml or mepivacaine 40 nig/ml or CSF bupivacaine 5 mg/ml. Acta Anaesthesiol. Scand. 42: 765-769.