Pharmacokinetics of human growth hormone administered subcutaneously with two different injection systems

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 7, 2001, Pages 613-617

  De la Motte, S ^a   Klinger, J ^a   Kefer, G ^a   King, T ^a   Harrison, F ^a  

^a NONE   (Germany)

Author keywords

CAS 12629 01 5; Human growth hormone, clinical pharmacokinetics, compartment model, subcutaneous injection; Somatropin

Indexed keywords

HUMAN GROWTH HORMONE;

AREA UNDER THE CURVE; ARTICLE; CANNULATION; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEVICE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; HORMONAL THERAPY; HUMAN; HUMAN EXPERIMENT; INJECTION; JET INJECTION; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

EID: 0034923865     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300089     Document Type: Article

References (10)

1. Pharmacokinetics and pharmacodynamics of recombinant human growth hormone by subcutaneous jet- or needle-injection in patients with growth hormone deficiency
2. Pharmacokinetics and pharmacodynamics of a single dose of recombinant human growth hormone after subcutaneous administration by jet-injection: Comparison with conventional needle-injection
3. Influence of concentration and injection volume on the bioavailability of subcutaneous growth hormone: Comparison of administration by ordinary syringe and by injection pen
4. The metabolic clearance rate, serum half-time and apparent distribution space of authentic biosynthetic human growth hormone in growth hormone-deficient patients
5. Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: Relationship to age, pubertal status, and body mass
6. Spontaneous pulsatility and pharmacokinetics of growth hormone in liver cirrhotic patients
7. Sample size determination for bioequivalence assessment by means of confidence intervals
8. A comparison of the two one-sided tests procedure and power approach for assessing the equivalence of average bioavailability
9. A distribution-free procedure for the statistical analysis of bioequivalence studies