Intra-articular injection of hyaluronate (SI-6601D) improves joint pain and synovial fluid prostaglandin E2 levels in rheumatoid arthritis: A multicenter clinical trial

Clinical and Experimental Rheumatology

Volumn 19, Issue 4, 2001, Pages 377-383

  Goto, M ^a   Hanyu, T ^a   Yoshio, T ^a   Matsuno, H ^a   Shimizu, M ^a   Murata, N ^a   Shiozawa, S ^a   Matsubara, T ^a   Yamana, S ^a   Matsuda, T ^a  

^a Tokyo Metropolitan Ohtsuka Hospital   (Japan)

Author keywords

Hyaluronate; PGE2; Rheumatoid arthritis; Synovial fluid

Indexed keywords

CHONDROITIN 4 SULFATE; CHONDROITIN 6 SULFATE; HYALURONIC ACID; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PROSTAGLANDIN E2; SI 6601D; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTHRALGIA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HUMAN; INFLAMMATION; MALE; MOLECULAR WEIGHT; MULTICENTER STUDY; PAIN ASSESSMENT; PASSIVE MOVEMENT; PATELLA; PATIENT MONITORING; PRIORITY JOURNAL; RATING SCALE; REST; RHEUMATOID ARTHRITIS; SIDE EFFECT; SYMPTOM; SYNOVIAL FLUID; WALKING;

ACTIVITIES OF DAILY LIVING; ADULT; AGED; ANIMALS; ARTHRALGIA; ARTHRITIS, RHEUMATOID; CHICKENS; CHONDROITIN SULFATES; COMB AND WATTLES; DINOPROSTONE; FEMALE; HUMANS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; JOINTS; MALE; MIDDLE AGED; SYNOVIAL FLUID; SYNOVITIS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TREATMENT OUTCOME; WALKING;

EID: 0034923078     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Clinical trial of intra-articular injection of sodium hyaluronate in patients with osteoarthritis of the knee
2. Preliminary clinical assessment of Na hyaluronate injection into human arthritic joints
3. Effects of hyaluronic acid on the release of proteoglycan from the cell matrix in rabbit chondrocyte culture in the presence and absence of cytokines
4. The lubrication in natural synovial joints and joint prostheses
5. Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats
6. Sodium hyaluronate (SPH): Studies on analgesic and anti-inflammatory effects of sodium hyaluronate (SPH)
7. Effects of hyaluronic acid on neutrophil adhesion
8. High-molecular-weight hyaluronic acids inhibit chemotaxix and phagocytosis but not lysosomal enzyme release induced by receptor-mediated stimulation in guinea pig phagocyte
9. Preincubation of human synovial cells with IL-1 modulates prostaglandin E2 release in response to bradykinin
10. Rheumatoid arthritis: A disease of T lymphocyte/macrophage immunoregulation
11. Hyaluronate inhibition of cell proliferation
12. The effect of high and low molecular weight hyaluronic acid on mitogen-induced lymphocyte proliferation
13. High molecular weight hyaluronic acids inhibit interleukin-1-induced prostaglandin E2 generation and prostaglandin E2-elicited cyclic AMP accumulation in human rheumatoid arthritic synovial cells
14. Intra-articular hyaluronic acid in the treatment of inflammatory and noninflammatory knee effusions
15. Biochemical analysis of rheumatoid synovial fluid after serial intra-articular injection of high molecular weight sodium hyaluronate
16. The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluid of patients with arthritis
17. Increase concentrations of proteoglycan components in the synovial fluids of patients acute but not chronic joint disease
18. Quantitation of chondroitin 4-sulfate and chondroitin 6-sulfate in pathologic synovial fluid
19. Potentiation of bradykinin-induced vascular permeability increase by prostaglandin E2 and arachidonic acid in rabbit skin
20. Potentiation of prostaglandins of the nociceptive activity of bradykinin in dog knee joint
21. The influence of intra-articular hyaluronic acid on PGE2 and cAMP of synovial fluid
22. Mucopolysaccharides in synovial fluid: Detection of chondroitin sulfate
23. Distribution of chondroitin 4-sulfate and chondroitin 6-sulfate in human articular and growth cartilage
24. Hyaluronan, cartilage destruction and hydrarthrosis in traumatic arthritis
25. Determination of chondroitin sulfates in human whole blood, plasma, blood cells by high-performance liquid chromatography
26. Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases