Enhancement of fibrogenesis by the p53 tumor suppressor protein in asbestos-exposed rodents

Chest

Volumn 120, Issue , 2001, Pages 33S-34S

  Nelson, Anne ^a   Mendoza, Tamra ^a,b   Brody, Arnold R ^a   Fermin, Cesar ^a   Morris, Gilbert F ^a  

^a Department of Pathology ^*  (United States)

^b TULANE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Asbestos; Epithelial growth factor receptor; Fibrosis; p53; Transforming growth factor

Indexed keywords

ASBESTOS; BROXURIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; PROTEIN P53; SURFACTANT PROTEIN C; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR ALPHA RECEPTOR;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; EXPOSURE; FIBROGENESIS; HISTOPATHOLOGY; LUNG ALVEOLUS EPITHELIUM; LUNG DEPOSIT; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RODENT; TRANSGENIC MOUSE;

ANIMALS; ASBESTOS; EPITHELIUM; LUNG; MICE; MICE, TRANSGENIC; PULMONARY FIBROSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034922777     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.120.1_suppl.S33     Document Type: Article

References (9)

1. Inhaled asbestos fibers induce p53 expression in the rat lung
2. Lung-specific expression in mice of a dominant negative mutant form of the p53 tumor suppressor protein
3. p53 stimulates transcription from the transforming growth factor alpha promoter: A potential growth-stimulatory role for p53
4. Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice
5. Transcriptional activation of the human epidermal growth factor receptor promoter by human p53
6. Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor
7. Reversal of lung lesions in transgenic transforming growth factor-α mice by expression of mutant epidermal growth factor receptor
8. Upregulated expression of transforming growth factor-α in the bronchiolar-alveolar duct regions of asbestos-exposed rats
9. Pulmonary fibrogenesis after three consecutive inhalation exposures to chrysotile asbestos