Concentrations of gatifloxacin in plasma and pulmonary compartments following a single 400 mg oral dose in patients undergoing fibre-optic bronchoscopy

Journal of Antimicrobial Chemotherapy

Volumn 48, Issue 1, 2001, Pages 63-66

  Honeybourne, D ^a   Banerjee, D ^a   Andrews, J ^b   Wise, R ^b  

^a BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^b CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; GATIFLOXACIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ARTICLE; BRONCHUS MUCOSA; CHLAMYDOPHILA PNEUMONIAE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; EPITHELIUM; FIBEROPTIC BRONCHOSCOPY; HAEMOPHILUS INFLUENZAE; HUMAN; LUNG ALVEOLUS MACROPHAGE; MEASUREMENT; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MYCOPLASMA PNEUMONIAE; STREPTOCOCCUS PNEUMONIAE; TIME;

EID: 0034922482     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/48.1.63     Document Type: Article

References (16)

1. Antimicrobial activity of gatifloxacin (AM-1155, CG5501), and four other fluoroquinolones tested against 2,284 recent clinical strains of Streptococcus pneumoniae from Europe, Latin America, Canada, and the United States
2. Anti-pneumococcal activity of gatifloxacin compared with other quinolone and non-quinolone agents
3. In vitro antimicrobial activity and penetration rate into sputum of gatifloxacin, a novel 6-fluoro-8-methoxy quinolone, and its therapeutic efficacy in respiratory infections
4. Pulmonary disposition of antimicrobial agents: Methodological considerations
5. Pharmacokinetics and pharmacodynamics of fluoroquinolones in the respiratory tract
6. Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa
7. Simplified, accurate method for antibiotic assay of clinical specimens
8. Antibiotic uptake by alveolar macrophages
9. Estimation of volume of epithelial lining fluid recovered by lavage using urea as a marker of dilution
10. A study to determine the pharmacokinetics and inflammatory fluid penetration of gatifloxacin following a single oral dose
11. Comparative bronchoalveolar concentrations of ciprofloxacin and lomefloxacin following oral administration
12. The use of in vitro pharmacodynamic models of infection to optimize fluoroquinolone dosing regimens
13. Relationship of high tissue concentrations of azithromycin to bacteriocidal activity and efficacy in vivo
14. Pharmacokinetics of four fluoroquinolones in an animal model of infected lung
15. Prophylactic and therapeutic activities of azithromycin in a mouse model of pneumococcal pneumonia
16. Concentrations of levofloxacin (HR 355) in the respiratory tract following a single oral dose in patients undergoing fibre-optic bronchoscopy