Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats

Kidney International

Volumn 60, Issue 2, 2001, Pages 715-721

  Cao, Zemin ^a,b   Burrell, Louise M ^a,b   Tikkanen, Ilkka ^a,b   Bonnet, Fabrice ^a,b   Cooper, Mark E ^a,b   Gilbert, Richard E ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

ACE inhibition; Cardiovascular therapy; Heart failure; Hypertension; Neutral endopeptidases; Progressive renal failure

Indexed keywords

CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FOSINOPRIL; OMAPATRILAT; RENIN; UREA; VASOPEPTIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; KIDNEY FIBROSIS; KIDNEY INJURY; MALE; NEPHRECTOMY; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROTEINURIA; RAT; UREA BLOOD LEVEL;

EID: 0034921566     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.060002715.x     Document Type: Article

References (28)

1. New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: Rational design, bioavailability, and pharmacological responses in experimental hypertension
2. Vasopeptidase inhibition: A new concept in blood pressure management
3. Deleterious effects of calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys
4. ACE inhibition and ANG II receptor blockade improve glomerular size-selectivity in IgA nephropathy
5. Effects of combination therapy with enalapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass ablation
6. Transforming growth factor β 1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system
7. Blockade of the renin-angiotensin and endothelin systems on progressive renal injury
8. Enkephalinase inhibition increases plasma atrial natriuretic peptide levels, glomerular filtration rate, and urinary sodium excretion in rats with reduced renal mass
9. Effects of neutral endopeptidase inhibition in the rat remnant kidney model
10. Protective effects of CGS 30440, a combined angiotensin-converting enzyme inhibitor and neutral endopeptidase inhibitor, in a model of chronic renal failure
11. Validation in awake rat of a tail-cuff method for measurement of systolic blood pressure
12. Antihypertensive therapy in a model combining spontaneous hypertension with diabetes
13. Evaluation of the Coomassie Brilliant blue G-250 method for urinary protein
14. A review of plasma renin measurements and their clinical significance
15. Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats
16. 125I-labelled MK351A
17. Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus
18. Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs
19. Angiotensin converting enzyme (ACE), characterization by 125I-MK351A binding studies of plasma and tissue ACE during variation of salt status in the rat
20. Identification and characterization of a neutral endopeptidase activity in aplysia-californica
21. Effects of omapatrilat in low, normal, and high renin experimental hypertension
22. Vasopeptidase inhibition has potent effects on blood pressure and resistance arteries in stroke-prone spontaneously hypertensive rats
23. Sustained antihypertensive actions of a dual angiotensin-converting enzyme neutral endopeptidase inhibitor, sampatrilat, in black hypertensive subjects
24. Lack of evidence of blood pressure-independent protection by renin- angiotensin system blockade after renal ablation
25. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti-transforming growth factor-beta antibody in db/db diabetic mice
26. Local actions of angiotensin II: Quantitative in vitro autoradiographic localization of angiotensin II receptor binding and angiotensin converting enzyme in target tissues
27. Acute and chronic effects of angiotensin-converting enzyme inhibitors on tissue angiotensin-converting enzyme
28. In vitro and in vivo inhibition of the 2 active sites of ACE by omapatrilat, a vasopeptidase inhibitor