PTEN: A newly identified regulator of neuronal differentiation

Neuroscientist

Volumn 7, Issue 4, 2001, Pages 278-281

  Ross, Alonzo H ^a   Lachyankar, Mahesh B ^b   Recht, Lawrence D ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Cowden disease; Glioma; Nerve growth factor (NGF); Neurogenesis; Phosphatase; Phosphatidylinositol 3 kinase; Tumor suppressor

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

AMINO ACID SEQUENCE; CYTOPLASM; HUMAN; MOLECULAR CLONING; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SEQUENCE ANALYSIS;

ANIMALS; CELL DIFFERENTIATION; HUMANS; NERVOUS SYSTEM; NEURONS; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 0034918984     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385840100700404     Document Type: Review

References (24)

1. Cellular survival: A play in three Akts
2. +/- mice
3. Pten is essential for embryonic development and tumour suppression
4. The tumor-suppressor activity of PTEN is regulated by its carboxylterminal region
5. Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene
6. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
7. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
8. Regulation of PTEN expression in neuronal apoptosis
9. A role for nuclear PTEN in neuronal differentiation
10. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
11. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β
12. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
13. Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells
14. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
15. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate
16. The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
17. The C. Elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
18. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
19. Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis
20. Negative regulation of PKB/ Akt-dependent cell survival by the tumor suppressor PTEN
21. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
22. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
23. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
24. Phosphorylation of the PTEN tail regulates protein stability and function