The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization

Placenta

Volumn 22, Issue 6, 2001, Pages 511-518

  Westerman, B A ^a   Poutsma, A ^a   Looijenga, L H J ^b   Wouters, D ^a   Van Wijk, I J ^a   Oudejans, C B M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; HELIX LOOP HELIX PROTEIN; HUMAN ACHAETE SCHUTE ASSOCIATED PROTEIN; HUMAN ACHAETE SCHUTE HOMOLOG 2 PROTEIN; HYBRID PROTEIN; MAMMALIAN ACHAETE SCUTE HOMOLOG 2; MESSENGER RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; FIRST TRIMESTER PREGNANCY; GENE FUNCTION; GENETIC TRANSFECTION; GENOME IMPRINTING; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; NUCLEOTIDE SEQUENCE; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECIES DIFFERENCE; TRANSLATION INITIATION;

EID: 0034916682     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1053/plac.2001.0695     Document Type: Article

References (23)

1. The human Achaete-Scute homologue 2 (ASCL2, HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts
2. Parental imprinting of the mouse H19 gene
3. Patterning of the Drosophila nervous system: The achaete-scute gene complex
4. Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development
5. Helix-loop-helix proteins as regulators of muscle-specific transcription
6. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1
7. From DNA to form: The achaete-scute complex
8. Genomic imprinting of Mash2, a mouse gene required for trophoblast development
9. Essential role of Mash-2 in extraembryonic development
10. An improved 5′RACE technique facilities the detection of multiple transcript initiation sites
11. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors
12. Isoform-Specific Imprinting of the Human PEG1/MEST Gene
13. Nucleolar and nuclear localization properties of a herpesvirus bZIP oncoprotein, MEQ
14. Heterogeneous X inactivation in trophoblastic cells of human full-term female placentas
15. The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1
16. A Sac, II polymorphism in the human ASCL2 (HASH2) gene region
17. Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2)
18. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse
19. The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
20. Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation
21. Mash2 acts cell autonomously in mouse spongiotrophoblast development
22. Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation
23. Identification of HASH2 extravillous trophoblast cells in the peripheral blood of pregnant women