Monotherapy comparative trials: Placebos and suboptimal comparators

Epilepsy Research

Volumn 45, Issue 1-3, 2001, Pages 93-96

  Schwabe, Stefan ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

Antiepileptic drugs; Comparative trials; Ethics; Monotherapy trials; Placebos

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; GABAPENTIN; LAMOTRIGINE; PHENYTOIN; PLACEBO; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

CLINICAL TRIAL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; DRUG TOLERABILITY; EPILEPSY; ETHICS; HOSPITAL PATIENT; HUMAN; INFANTILE SPASM; MAJOR CLINICAL STUDY; MONOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEIZURE;

ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; HUMANS; RESEARCH DESIGN;

EID: 0034914788     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(01)00226-1     Document Type: Conference Paper

References (6)

1. Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms
2. A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures
3. Lamictal (lamotrigine) monotherapy for typical absence seizures in children
4. An active-control trial of lamotrigine monotherapy for partial seizures
5. Monotherapy trials with the new antiepileptic drugs: Study designs, practical relevance and ethical implications
6. Topiramate monotherapy for partial onset seizures