2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: Role of inhibition of transforming growth factor-β1 expression

Pharmacology and Toxicology

Volumn 89, Issue 1, 2001, Pages 23-29

  Kang, Keon Wook ^a   Ha, Jong Ryul ^b   Kim, Choon Won ^c   Kim, Nak Doo ^a   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

^b Choong Wae Research Laboratory   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ALLYLTHIO)PYRAZINE; ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYTOCHROME P450 2E1; DIMETHYLNITROSAMINE; GAMMA GLUTAMYLTRANSFERASE; MESSENGER RNA; NITROSAMINE; PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; LIVER CIRRHOSIS; LIVER FIBROSIS; MALE; NONHUMAN; OCCUPATIONAL HAZARD; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR;

ANIMALIA;

EID: 0034913988     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2001.d01-131.x     Document Type: Article

References (30)

1. Ala-Kokko, L., T. Pihlajaniemi, J. C. Myers, K. I. Kivirikko & E. R. Savolainen: Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat. Biochem. J. 1987, 244, 75-79.
2. Beutler, B. & V. Kruys: Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. J. Cardiovasc. Pharmacol. 1995, 25, S1-S8.
3. Chao, Y. C., T. H. Young, W. K. Chang, H. S. Tang & C. T. Hsu: An investigation of whether polymorphisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population. Hepatology 1995, 22, 1409-1414.
4. Cheever, A. W., D. Jankovic, G. S. Yap, M. C. Kullberg, A. Sher & T. A. Wynn: Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice. Mem. Inst. Oswaldo. Cruz. 1998, 93, 25-32.
5. Clouthier, D. E., S. A. Comerford & R. E. Hammer: Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-β1 transgenic mice, J. Clin. Invest. 1997, 100, 2697-2713.
6. Freidman, S. L.: The cellular basis of hepatic fibrosis. New Eng. J. Med. 1993, 328, 1828-1835.
7. George, J. & G. Chandrakasan: Molecular characteristics of dimethylnitrosamine-induced fibrotic liver collagen. Biochim. Biophys. Acta 1996, 1292, 215-222.
8. George, J., D. Roulot, V. E. Koteliansky & B. D. Montgomery: In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis. Proc. Natl. Acad. Sci. 1999, 96, 12719-12724.
9. 1-induced hepatocarcinogenesis in rats. Chem. Biol Interact. 1999, 121, 209-222.
10. Jejävquel, A. M., R. Mancini, M. L. Rinaldesi, G. Macarri, C. Venturini & F. Orlandi: A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat. J. Hepatol. 1987, 5, 174-181.
11. Kim, N. D. & S. G. Kim: Chemopreventive effects of 2-(allylthio)pyrazine. Arch. Pharm. Res. 1999, 22, 99-107.
12. Kim, N. D., M. K. Kwak & S. G. Kim: Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: Hepatoprotective effects. Biochem. Pharmacol. 1997a, 53, 261-269.
13. Kim, N. D., K. W. Kang, S. G. Kim & V. B. Schini-Kerth: Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia. Biochem. Biophys. Res. Commun. 1997b, 239, 310-315.
14. Kim, S. G., M. K. Cho, S. H. Choi, H. J. Kim, M. K. Kwak & N. D. Kim: Molecular basis for hepatic detoxifying enzyme induction by 2-(allylthio)pyrazine in rats in comparison with oltipraz: Effects on prooxidant production and DNA degradation. Drug Metab. Disp. 1999, 27, 667-673.
15. Kimura, K., K. Ando, H. Ohnishi, T. Ishikawa, S. Kakumu, M. Takemura, Y. Muto & H. Moriwaki: Immunopathogenesis of hepatic fibrosis in chronic liver injury induced by repeatedly administered concanavalin A. Int. Immunol 1999, 11, 1491-1500.
16. Koop, D. R.: Oxidative and reductive metabolism by cytochrome P4502E1. FASEB J. 1992, 6, 724-730.
17. Kunstle, G., H. Hentze, P. G. Germann, G. Tiegs, T. Meergans & A. Wendel: Concanavalin A hepatotoxicity in mice: Tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation. Hepatology 1999, 30, 1241-1251.
18. Moragas, A., H. Allende & M. Sans: Characteristics of perisinusoidal collagenization in liver cirrhosis: Computer-assisted quantitative analysis. Anal. Quant. Cytol. Histol. 1998, 20, 169-177.
19. Park, R. M. & F. E. Mirer: A survey of mortality at two automotive engine manufacturing plants. Amer. J. Ind. Med. 1996, 30, 664-673.
20. Peng, R., Y. Y. Tu & C. S. Yang: The induction and competitive inhibition of a high affinity nitrosodimethylamine demethylase by ethanol. Carcinogenesis 1982, 3, 1457-1461.
21. Pinzani, M., F. Marra & V. Carloni: Signal transduction in hepatic stellate cells. Liver 1998, 18, 2-13.
22. Qi, Z., N. Atsuchi, A. Ooshima, A. Takeshita & H. Ueno: Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc. Natl. Acad. Sci. 1999, 96, 2345-2349.
23. Sakaida, I., M, Kubota, K, Kayano, K, Takenaka, K, Mori & K, Okita: Prevention of fibrosis reduces enzyme-altered lesions in the rat liver. Carcinogenesis 1994, 15, 2201-2206.
24. Savolainen, E. R., D. Brocks, L. Ala-Kokko & K. I. Kivirikko: Serum concentration of the N-terminal peptide of type III procollagen and two type IV collagen fragments and gene expression of the respective collagen types in liver in rats with dimethylnitrosamine-induced hepatic fibrosis. Biochem. J. 1988, 249, 753-757.
25. Schumann, J., S. Angermuller, R. Bang, M. Lohoff & G. Tiegs: Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF. J. Immunol. 1998, 161, 5745-5754.
26. Straif, K., S. Weiland, B. Werner, A. Wienke & U. Keil: Elevated mortality from nonalcohol-related chronic liver disease among female rubber workers: Is it associated with exposure to nitrosamines? Amer. J. Ind. Med. 1999, 35, 264-271.
27. Surh, Y. J., S. G. Kim, K. K. Park, Y. W. Sohn, J. M. Lee, N. D. Kim & J. A. Miller: Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide. Carcinogenesis 1998, 19, 1263-1267.
28. Sørensen, H. T., S. Friis, J. H. Olson, A. M. Thulstrup, L. Mellemkær, M. Linet, D. Trichopoulos, H. Vilstrup & J. Olson: Risk of liver and other types of cancer in patients with cirrhosis: a nationwide cohort study in Denmark. Hepatology 1998, 28, 921-925.
29. Tsukamoto, H., M. Matsuoka & S. W. French: Experimental models of hepatic fibrosis: A review. Semin. Liv. Dis. 1990, 10, 56-63.
30. Yamazaki, H., Y. Inui, C. H. Yun, F. P. Guengerich & T. Shimada: Cytochrome P450 2E1 and 2A6 enzymes as major catalysis for metabolic activation of N-nitrosoalkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis 1992, 13, 1789-1794.