Mercurial sensitivity of aquaporin 1 endofacial loop B residues

Protein Science

Volumn 10, Issue 8, 2001, Pages 1627-1634

  Kuang, Kunyan ^a   Haller, Jorge F ^a   Shi, Guangpu ^a   Kang, Fengying ^a,b   Cheung, Min ^a,c   Iserovich, Pavel ^a   Fischbarg, Jorge ^a,d  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c WEIFANG MEDICAL UNIVERSITY   (China)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hourglass model; Osmotic permeability; Pore; Water channel

Indexed keywords

AQUAPORIN 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CRYSTALLOGRAPHY; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; WATER PERMEABILITY;

AMINO ACID MOTIFS; ANIMALS; AQUAPORIN 1; AQUAPORINS; COMPUTER SIMULATION; MERCURY COMPOUNDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PERMEABILITY; PROTEIN STRUCTURE, TERTIARY; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0034913809     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.5901     Document Type: Article

References (18)

1. Acetylcholine receptor channel structure probed in cysteine-substitution mutants
2. Three-dimensional organization of a human water channel
3. The MIP transmembrane channel family
4. Solvent-accessible surfaces of proteins and nucleic acids
5. Cultured bovine corneal endothelial cells express CHIP28 water channels
6. Structure of a glycerol-conducting channel and the basis for its selectivity
7. Structural clues in the sequences of the aquaporins
8. Molecular structure of the water channel through aquaporin CHIP. The hourglass model
9. The structure of aquaporin-1 at 4.5-A resolution reveals short alpha- helices in the center of the monomer
10. Structural determinants of water permeation through aquaporin-1
11. Isolation of the cDNA for erythrocyte membrane protein of 28 kilodaltons: Member of an ancient channel family
12. The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel
13. Three-dimensional fold of the human AQP1 water channel determined at 4 A resolution by electron crystallography of two-dimensional crystals embedded in ice
14. Visualization of a water-selective pore by electron crystallography in vitreous ice
15. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: Helix X
16. Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution
17. A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes
18. A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k