Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells

Anticancer Research

Volumn 21, Issue 3 B, 2001, Pages 1763-1770

  Mata Greenwood, E ^a   Ito, A ^a   Westenburg, H ^a   Cui, B ^a   Mehta, R G ^a   Kinghorn, A D ^a   Pezzuto, J M ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Chemoprevention; Differentiation; Differentiation therapy; Flavones; HL 60 cells; Lignans; Natural products; Polysulfides

Indexed keywords

2 [(PHENYLMETHYL)DITHIO]ETHANOL; 2',5,6 TRIMETHOXYFLAVONE; AGLAIA PONAPENSIS EXTRACT; CASIMIROA EDULIS EXTRACT; DIBENZYLTRISULFIDE; FLAVONOID; NATURAL PRODUCT; NORROCAGLAMIDE; PETIVERIA ALLIACEA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; ZAPOTIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL ASSAY; CARCINOGENS; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; ESTERASES; HL-60 CELLS; HUMANS; INDICATORS AND REAGENTS; MAMMARY NEOPLASMS, ANIMAL; MICE; MODELS, CHEMICAL; NEOPLASMS; NITROBLUE TETRAZOLIUM; ORGAN CULTURE TECHNIQUES; PLANT EXTRACTS;

EID: 0034910507     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Neoplasia: A disease of cell differentiation
2. Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia
3. Constitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia: A model for the origin and progression of malignancy
4. Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982)
5. Characterization of mononuclear blood cell-derived differentiation inducing factors for the human promyelocytic leukemic cell line HL-60
6. Study of differentiation of fresh myelogenous leukemic cells by compounds that induce human promyelocytic leukemic line (HL-60) to differentiate
7. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results
8. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
9. Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia
10. Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors
11. Mechanistic considerations in chemopreventive drug development
12. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck
13. Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis
14. Adjuvant treatment of stage I lung cancer with high-dose vitamin A
15. Recent advances in chemoprevention of cancer
16. The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression
17. Natural product cancer chemopreventive agents
18. Cytochemical identification of monocytes and granulocytes
19. Regulation of myeloperoxidase gene expression during differentiation of human myeloid leukemia HL-60 cells
20. A combination of a T cell-derived lymphokine differentiation-inducing activity, and a physiologic concentration of retinoic acid induces HL-60 to differentiate to cells with functional chemotactic receptors
21. Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds
22. Normal functional characteristics of cultured human promyelocytic leukemia cells after induction of differentiation by dimethylsulfoxide
23. Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line
24. Antimutagenic constituents of Casimiroa edulis with potential cancer chemopreventive activity
25. Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model
26. Characterization of effective, chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol
27. Genistein as an inducer of tumor cell differentiation: Possible mechanisms of action
28. In vitro antiproliferative activity of Petiveria alliacea L. on several tumor cell lines
29. Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta [b]benzofuran lignans isolated from Aglaia elliptica
30. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid
31. HL-60 cell differentiation induced by phorbol- and 12-deoxyphorbol-esters
32. Diterpenoid irritants and cocarcinogens in Euphorbiaceae and Thymelaeaceae: Structural relationships in view of their biogenesis
33. Cocarcinogenic irritant Euphorbiaceae
34. Genistein a specific inhibitor of tyrosine-specific protein kinases
35. Diallyl sulfide, a flavor component of garlic (Allium sativum) inhibits dimethylhydrazine induced colon cancer
36. Onion and garlic oils inhibit tumor formation
37. Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents
38. Pharmacodynamics and toxicodynamics of drug action: Signaling in cell suvival and cell death
39. HL-60 cells isolated for resistance to vincristine are defective in 12-O-tetradecanoylphorbol -13-acetate induced differentiation and the formation of a functional AP-1 complex
40. Effect of 1-αd-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-jun dominant-negative mutant protein (TAM67)
41. Inhibition of phorbol ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun (AP-1)
42. Redox regulation of transcriptional activators
43. Inhibition of differentiation of human myeloid cell lines by redox changes induced through glutathione depletion
44. Dithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage
45. Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells