Alteration of drug kinetics in rats following exposure to trichloroethylene

Pharmacology

Volumn 63, Issue 2, 2001, Pages 90-94

  Kukongviriyapan, Veerapol ^a   Simajareuk, Suthanee ^a   Kukongviriyapan, Upa ^a   Cha On, Ubon ^a   Airarat, Wanchai ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Chlorinated solvent; Cytochrome P 450; Trichloroethylene

Indexed keywords

CORN OIL; CYTOCHROME P450; PENTOBARBITAL; QUINIDINE; THEOPHYLLINE; TRICHLOROETHYLENE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SLEEP TIME;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; HYPNOTICS AND SEDATIVES; MALE; PENTOBARBITAL; PHARMACOKINETICS; PHOSPHODIESTERASE INHIBITORS; QUINIDINE; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; SOLVENTS; THEOPHYLLINE; TRICHLOROETHYLENE;

EID: 0034910245     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056118     Document Type: Article

References (32)

1. Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons
2. Pretreatment with drinking water solutions containing trichloroethylene or chloroform enhances the hepatoxicity of carbon tetrachloride in Fischer 344 rats
3. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
4. Effect of exposure to four organic solvents on hepatic cytochrome P450 isozymes in rat
5. Cytochrome-P450-dependent metabolism of trichloroethylene: Interindividual differences in humans
6. Effect of ethanol on the metabolism of trichloroethylene
7. Metabolism and mutagenicity of halogenated olefins: A comparison of structure and activities
8. Immunochemical detection of protein adducts in mice treated with trichloroethylene
9. Delineation of the role of metabolism in the hepatoxicity of trichloroethylene and perchloroethylene: A dose-effect study
10. Inhibition, activation, destruction, and induction of drug metabolizing enzymes by trichloroethylene
11. Dose-dependent induction and suppression of liver mixed-function oxidase system in chlorinated hydrocarbon solvent metabolism
12. Dose-dependent metabolism of trichloroethylene and its relevance to hepatotoxicity in rats
13. Influence of organic solvents on the anticoagulant response to warfarin in rats
14. Effects of chlorinated solvent exposure on hepatic transport of anionic dyes in the rats
15. The carbon monoxide-binding pigment of liver microsomes
16. Protein measurement with the Folin phenol reagent
17. Mechanism of trichloroethylene-induced elevation of individual serum bile acids. II. In vitro and in vivo interference by trichloroethylene with bile acid transport in isolated rat hepatocytes
18. Mechanism of trichloroethylene-induced elevation of individual serum bile acids. I. Correlation of trichloroethylene concentrations to bile acids in rat serum
19. Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content
20. Chronic inhalation effects of trichloroethylene on hepatic microsomal mixed-function oxidase system in rats
21. Induction of cytochrome P-450, cytochrome b-5, NADPH-cytochrome c reductase and change of cytochrome P-450 isozymes with long-term trichloroethylene treatment
22. In vivo evidence that theophylline is metabolized principally by CYP1A in rats
23. Pharmacokinetic optimisation of asthma treatment
24. The influence of increased plasma protein binding on the disposition of quinidine in turpentine-treated rats
25. Induction of microsomal cytochrome P-450 enzymes
26. Molecular genetics of the P-450 superfamily
27. Glycine and gamma-aminobutyric acid (A) receptor function is enhanced by inhaled drugs of abuse
28. Hypnotics and sedatives: Ethanol