Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules

Immunological Reviews

Volumn 181, Issue , 2001, Pages 66-78

  Boyington, Jeffrey C ^a   Brooks, Andrew G ^b   Sun, Peter D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HLA C ANTIGEN; IMMUNOGLOBULIN RECEPTOR; LECTIN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; BINDING AFFINITY; CRYSTAL STRUCTURE; CYTOLYSIS; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, LY; BINDING SITES; CARRIER PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-C ANTIGENS; HUMANS; HYDROGEN BONDING; LECTINS, C-TYPE; LIGANDS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; RECEPTORS, IMMUNOLOGIC; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0034909777     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1810105.x     Document Type: Review

References (84)

1. NK cell receptors
2. Regulation of immune responses through inhibitory receptors
3. + IL-2-activated natural killer cells
4. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis
5. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
6. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A
7. b
8. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
9. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
10. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
11. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages
12. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains
13. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells
14. Molecular cloning of NKB1. A natural killer cell receptor for HLAB allotypes
15. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities
16. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells
17. NKB1: A natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules
18. Alternatively spliced forms of human killer inhibitory receptors
19. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
20. Nucleotide and amino acid sequence alignment for human killer cell inhibitory receptors (KIR)
21. Genomic organization of a human killer cell inhibitory receptor gene
22. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
23. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathway
24. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
25. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
26. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
27. Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily
28. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells
29. Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors
30. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors
31. Crystal structure of the HLA-Cw3 allotype-specific killer cell inbibitory receptor KIR2DL2
32. Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I
33. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2)
34. Crystal structure of the human leukocyte Fc receptor, FcγRIIa
35. Crystal structure of the soluble form of the human fcγ-receptor IIb: A new member of the immunoglobulin superfamily at 1.7 Å resolution
36. Crystal structure of the human high-affinity IgE receptor
37. Crystal structure of the extracellular domain of a human FcγRII
38. Natural killer susceptibility of human cells may be regulated by genes in the HLA region on chromosome 6
39. NK susceptibility varies inversely with target cell class I HLA antigen expression
40. Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell-mediated lysis is inversely correlated with HLA class I antigen expression
41. + natural killer (NK) cells by the expression of clonally distributed functional surface molecules: Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition
42. Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition
43. Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: Expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2)
44. HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells
45. Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C
46. The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor
47. Killer cell inhibitory receptors specific for HLA-C and HLA-B dentified by direct binding and by functional transfer
48. Inhibitory MHC class I receptors on NK and T cells: A standard nomenclature
49. Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule
50. The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity
51. Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors
52. Binding of a soluble p70 killer cell inhibitory receptor to HLA-B*5101: Requirement for all three p70 immunoglobulin domains
53. Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties
54. The natural killer cell receptor specific for HLA-A allotypes: A novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer
55. A human killer inhibitory receptor specific for HLA-A1,2
56. A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells
57. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
58. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
59. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex
60. Atomic structure of an αβ T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody
61. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
62. TCR binding to peptide-MHC stabilizes a flexible recognition interface
63. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors
64. Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor
65. The binding site of NK receptors on HLA-C molecules
66. The inter-locus recombinant HLAB*4601 has high selectivity in peptide binding and functions characteristic of HLA-C
67. A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors
68. Human diversity in killer cell inhibitory receptor genes
69. Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells
70. A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLAB*2705
71. Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis
72. Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor
73. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand
74. Mapping the ligand of the NK inhibitory receptor Ly49A on living cells
75. The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand
76. Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD941/NKG2 receptors
77. Crystal structure of human CD69: A C-type lectin-like activation marker of hematopoietic cells
78. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
79. Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 Å
80. Three-dimensional segregation of supramolecular activation dusters in T cells
81. The immunological synapse: A molecular machine controlling T cell activation
82. The human natural killer cell immune synapse
83. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
84. Raster 3D version 2.0: A program for photorealistic molecular graphics