Protection of U937 cells from free radical damage by the macrophage synthesized antioxidant 7,8-dihydroneopterin

Free Radical Research

Volumn 35, Issue 3, 2001, Pages 311-318

  Gieseg, S P ^a   Whybrow, J ^a   Glubb, D ^a   Rait, C ^a  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Antioxidant; Free radical; Hypochlorite; Macrophage; Neopterin; Peroxidation

Indexed keywords

7,8 DIHYDRONEOPTERIN; ANTIOXIDANT; CELL PROTEIN; FERROUS ION; FREE RADICAL; GAMMA INTERFERON; HYPOCHLORITE; NEOPTERIN; PROTEIN HYDROLYSATE; PTERIN DERIVATIVE; SCAVENGER; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STIMULATION; CELL STRAIN U937; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION FUNCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INHIBITION KINETICS; LIPID PEROXIDATION; MACROPHAGE; OXIDATIVE STRESS; PROTEIN SYNTHESIS;

EID: 0034909594     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100300841     Document Type: Article

References (25)

1. Neopterin modulates toxicity mediated by reactive oxygen and chloride species
2. Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neoptern dependents on the presence of iron chelator complex
3. 7,8-Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant
4. Protection of erythrocytes by the macrophage synthesized antioxidant 7,8-dihydroneopterin
5. Inhibition of haemolysis by the macrophage synthesized antioxidant, 7,8-dihydroneopterin
6. Inhibition of luminol enhanced chemiluminescence by reduced pterins
7. Effects of pteridines on chloramine-T-induced growth inhibition in E. coli strains: Correlations with molecular structure
8. Spin trapping study of antioxidant properties of neopterin and 7,8-dihydroneopterin
9. Inhibitory effects of neopterin on NADPH-dependent superoxide-generating oxidase of rat peritoneal macrophages
10. Inhibition of xanthine oxidase by pterins
11. Dityrosine: A marker for oxidatively modified proteins and selective proteolysis
12. Measurement of reaction products from hypochlorous acid and unsaturated lipids
13. Isolation and use of liver cells
14. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
15. Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides
16. Improved analysis of malondialdehyde in human body fluids
17. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials
18. Protein bound 3,4-dihydroxyphenylalanine is a major reductant formed during hydroxyl radical damage to proteins
19. Protein hydroperoxides, protein hydroxides and protein bound DOPA
20. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties
21. Free radical and enzymatic mechanisms for the generation of protein bound reducing moieties
22. Mechanisms of hypochlorite injury of target cells
23. Mechanisms of Oxidant-mediated cell injury
24. P-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes: A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase