Development of an improved automated gas-chromatographic chiral analysis system: Application to non-natural amino acids and natural protein hydrolysates

Chirality

Volumn 13, Issue 8, 2001, Pages 431-434

  Nokihara, Kiyoshi ^a,c   Gerhardt, Jürgen ^b  

^a Shimadzu Scientific Research Inc   (Japan)

^b Chromatographic und Analysen Technik   (Germany)

^c Shimadzu Scientific Research Inc   (Japan)

Author keywords

Autoderivatizer; Enantioselective column; Gas chromatography; Mass spectrometry; Milk proteins; Natural amino acids; Non natural amino acids; Protein hydrolysates; Tissue proteins

Indexed keywords

AMINO ACID; PROTEIN HYDROLYSATE;

ACYLATION; ANALYTIC METHOD; AUTOMATION; CHIRALITY; COMBINATORIAL CHEMISTRY; CONFERENCE PAPER; DERIVATIZATION; ENANTIOMER; ESTERIFICATION; GAS CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN ANALYSIS; STEREOISOMERISM;

AGED; AGED, 80 AND OVER; AMINO ACIDS; BRAIN CHEMISTRY; CHROMATOGRAPHY, GAS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROLYSIS; MIDDLE AGED; MILK PROTEINS; NERVE TISSUE PROTEINS; PROTEINS; STEREOISOMERISM;

EID: 0034908882     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.1057     Document Type: Conference Paper

References (9)

1. Gallop MA, Barnett RW, Dower WJ, Fodor PA, Gordon EM. Application of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem 1994;37:1233-1251.
2. Gerhardt J, Nokihara K, Yamamoto R. Design and applications of a novel amino acid analyzer for D/L and quantitative analysis with the use of gas chromatography. In: Smith JA, Rivier JE, editors. Peptides: chemistry, structure and biology. Leiden: Escom Science Publishers BV; 1992. p 531-532.
3. Nokihara K, Yamamoto R, Nishine T, Gerhardt J. Instrumentation and applications of a novel amino acid analyzer, Shimadzu-CAT DLAA-1. In: Takai K, editor. Frontiers and horizons in amino acid research. Amsterdam: Elsevier Science Publishers BV; 1992. p 391-395.
4. Frank H, Nicholson GJ, Bayer E. Enantiomer labeling, a method for the quantitative analysis of amino acids. J Chromatogr 1978;167:187196.
5. Frank, H, Nicholson, GJ and Bayer, E. Rapid gas Chromatographic separation of amino acid enantiomers with a novel chiral stationary phase. J Chromatogr Sci 1977;15:174-176.
6. Schurig V, Juza M, Preschel M, Nicholson GJ, Bayer E. Gaschromatographic enantiomer separation of proteinogenic amino acid derivatives: comparison of Chirasil-Val and Chirasil-γ-Dex used as chiral stationary phases. Enantiomer 1999;4:297-303.
7. Bada JL. Racemization of amino acids. In: Barrett GC, editor. Chemistry and biochemistry of the amino acids. New York: Chapman and Hall; 1985. p 399-414.
8. Frank H, Woiwode W, Nicholson GJ, Bayer E. Determination of optical purity of amino acids in proteins. In: Kein E, Kein PP, editors. Stable isotopes. New York: Academic Press; 1979. p 165-172.
9. Gerhardt J, Nicholson GJ. Unambiguous determination of the optical purity of peptides via GC-MS. In: Hodges RS, Smith JA, editors. Peptides: chemistry, structure and biology. Leiden: Escom Science Publishers BV; 1994. p 241-243.