Pharmacological evaluation and chemical stability of 2-benzylthioether-5′-O-(1-Thiotriphosphate)-adenosine, a new insulin secretagogue acting through P2Y receptors

Drug Development Research

Volumn 53, Issue 1, 2001, Pages 33-43

  Hillaire Buys, D ^a,b   Shahar, L ^a,b   Fischer, B ^a,b   Chulkin, A ^a,b   Linck, N ^a,b   Chapal, J ^a,b   Loubatieres Mariani M M ^a,b   Petit, P ^a,b  

^a UNIV MONTPELLIER   (France)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

Chemical stability; Insulin secretion; P2 receptor; P2Y ligand; Vascular resistance

Indexed keywords

2 BENZYLTHIOETHER 5' O (1 THIOTRIPHOSPHATE)ADENOSINE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; GLUCOSE; INSULIN; INSULIN I 125; PHOSPHOROTHIOIC ACID; PURINE P2Y RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESULFURIZATION; DIASTEREOISOMER; DOSE TIME EFFECT RELATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG STABILITY; GLUCOSE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; HYPERGLYCEMIA; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH ABSORPTION; STOMACH PH; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0034907429     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1167     Document Type: Article

References (2)

1. Armitage P. 1980. Biological assay. In: Armitage P, editor. Statistical methods in medical research. Oxford: Blackwell Scientific Publications, p 442-456.
2. 2-purinoceptors on β cell and pancreatic vascular bed. Br J Pharmacol 91:783-787.